|
==Espressione di PCNA all'interno del nucleo durante la sintesi del DNA==
PCNA è stata originariamente identificata come un [[antigene]] espresso nei nuclei delle cellule durante la fase di sintesi del DNA <ref name="pmid1350788">{{Cita pubblicazione | autore = Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Dalla Palma P, Barbareschi M | titolo = PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables | rivista = J. Clin. Pathol. | volume = 45 | numero = 5 | pagine = 416–9 | anno = 1992 | pmid id=PMID 1350788 | doi = 10.1136/jcp.45.5.416 }}</ref>. Parte della proteina è stata sequenziata e la sequenza è stata utilizzata per consentire l'isolamento di un clone a [[cDNA]] <ref name="pmid2884104">{{Cita pubblicazione | autore = Matsumoto K, Moriuchi T, Koji T, Nakane PK | titolo = Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin | rivista = Embo J. | volume = 6 | numero = 3 | pagine = 637–42 | anno = 1987 | pmid id=PMID 2884104 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=2884104 }}</ref>. PCNA aiuta a mantenere la DNA polimerasi delta (Pol δ) ancorata al DNA. PCNA viene bloccato <ref name="Bowman_2004">{{Cita pubblicazione | autore = Bowman GD, O'Donnell M, Kuriyan J | titolo = Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex | rivista = Nature | volume = 429 | numero = 6993 | pagine = 724–30 | anno = 2004 | pmid id=PMID 15201901 | doi = 10.1038/nature02585 }}</ref> al DNA attraverso l'azione del ''fattore di replicazione C'' (RFC) <ref name="pmid10051561">{{Cita pubblicazione | autore = Zhang G, Gibbs E, Kelman Z, O'Donnell M, Hurwitz J | titolo = Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen | rivista = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | numero = 5 | pagine = 1869–74 | anno = 1999 | pmid id=PMID 10051561 | doi = 10.1073/pnas.96.5.1869 | pmc=26703}}</ref>, il quale fa parte degli eteropentameri della classe AAA+ ATPasi dipendenti. L'espressione del gene PCNA è sotto il controllo del fattore di trascrizione E2F <ref name="pmid12468739">{{Cita pubblicazione | autore = Egelkrout EM, Mariconti L, Settlage SB, Cella R, Robertson D, Hanley-Bowdoin L | titolo = Two E2F elements regulate the proliferating cell nuclear antigen promoter differently during leaf development | rivista = Plant Cell | volume = 14 | numero = 12 | pagine = 3225–36 | anno = 2002 | pmid id=PMID 12468739 | doi = 10.1105/tpc.006403 }}</ref>.
==Ruolo di PCNA nella riparazione del DNA==
La DNA polimerasi delta è coinvolta nella sintesi di filamenti di DNA danneggiati e quindi rimossi durante la riparazione del DNA, PCNA consentendo alla DNA polimerasi delta il contatto con il filamento danneggiato svolge un ruolo importante sia per la sintesi del DNA che per la sua riparazione <ref name="pmid1348971">{{Cita pubblicazione | autore = Shivji KK, Kenny MK, Wood RD | titolo = Proliferating cell nuclear antigen is required for DNA excision repair | rivista = Cell | volume = 69 | numero = 2 | pagine = 367–74 | anno = 1992 | mese=aprile| pmid id=PMID 1348971 | doi = | url = }}</ref><ref name="pmid16227586">{{Cita pubblicazione | autore = Essers J, Theil AF, Baldeyron C, van Cappellen WA, Houtsmuller AB, Kanaar R, Vermeulen W | titolo = Nuclear dynamics of PCNA in DNA replication and repair | rivista = Mol. Cell. Biol. | volume = 25 | numero = 21 | pagine = 9350–9 | anno = 2005 | pmid id=PMID 16227586 | doi = 10.1128/MCB.25.21.9350-9359.2005 }}</ref>.
PCNA interviene anche nella via di tolleranza danno al DNA denominata riparazione post-replicazione (''post-replication repair o PRR'') <ref name="pmid16956796">{{Cita pubblicazione | autore = Lehmann AR, Fuchs RP | titolo = Gaps and forks in DNA replication: Rediscovering old models | rivista = DNA Repair (Amst.) | volume = 5 | numero = 12 | pagine = 1495–8 | anno = 2006 | mese=dicembre| pmid id=PMID 16956796 | doi = 10.1016/j.dnarep.2006.07.002 | url = }}</ref> In PRR, avvengono due sotto-percorsi:
* Il percorso translesione, che viene svolto da DNA polimerasi specializzate in grado di integrare le basi del DNA danneggiato nei loro siti attivi (a differenza delle normali polimerasi replicative), e quindi evitare il danno.
* Il superamento del danno tramite il reclutamento dei meccanismi di [[Ricombinazione genetica|ricombinazione]] degli omologhi.
PCNA è fondamentale per l'attivazione di questi percorsi e per la scelta di quale percorso di riparazione viene utilizzato dalla cellula.</br>
La proteina PCNA subisce [[Ubiquitina|modifiche post-traduzionali quali ubiquitinazione]] <ref name="Hoege_2002">{{Cita pubblicazione | autore = Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S | titolo = RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO | rivista = Nature | volume = 419 | numero = 6903 | pagine = 135–41 | anno = 2002 | mese=settembre| pmid id=PMID 12226657 | doi = 10.1038/nature00991 | url = }}</ref>: Se la lisina numero 164 del peptide viene mono-ubiquinata si avrà l'attivazione del meccanismo di riparazione translesione, Se invece si verifica una poli-ubiquitinazione che coinvolge la lisina 63 <ref name="Hoege_2002"/>, si attiverà il secondo percorso di riparazione. Inoltre, se la lisina-164 (ed in misura minore, la lisina-127) di PCNA vanno incontro al processo di sumolazione (piccole modificatore ubiquitino-simili, SUMO) viene inibito il secondo percorso di riparazione <ref name="Hoege_2002"/>. Questo effetto di inibizione nella riparazione si verifica perché la PCNA sumolata, recluta un DNA elicasi denominato Srs2 <ref name="pmid15931174">{{Cita pubblicazione | autore = Pfander B, Moldovan GL, Sacher M, Hoege C, Jentsch S | titolo = SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase | rivista = Nature | volume = 436 | numero = 7049 | pagine = 428–33 | anno = 2005 | mese=luglio| pmid id=PMID 15931174 | doi = 10.1038/nature03665 | url = }}</ref>, tale elicasi disturba l'azione della nucleoproteina RAD51 la quale è fondamentale per l'inizio della ricombinazione omologa <ref name="pmid15931174"/>.
==Interazioni==
PCNA può interagire con: [[Ku70]],<ref name=pmid12171929>{{Cita pubblicazione | quotes = yes |cognome=Ohta |nome=Satoshi |linkautore= |coautori=Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki |anno=[[2002]]|mese=Oct. |titolo=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |rivista=J. Biol. Chem. |volume=277 |numero=43 |pagine=40362–7 |publisher= |___location = United States| issn = 0021-9258| pmid = 12171929 |doi = 10.1074/jbc.M206194200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11239001>{{Cita pubblicazione | quotes = yes |cognome=Balajee |nome=A S |linkautore= |coautori=Geard C R |anno=[[2001]]|mese=Mar. |titolo=Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells |rivista=Nucleic Acids Res. |volume=29 |numero=6 |pagine=1341–51 |publisher= |___location = England| issn = | pmid = 11239001 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1093/nar/29.6.1341 | pmc=29758}}</ref> [[MSH3]],<ref name=pmid12171929/><ref name=pmid11274057>{{Cita pubblicazione | quotes = yes |cognome=Kleczkowska |nome=H E |linkautore= |coautori=Marra G, Lettieri T, Jiricny J |anno=[[2001]]|mese=Mar. |titolo=hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci |rivista=Genes Dev. |volume=15 |numero=6 |pagine=724–36 |publisher= |___location = United States| issn = 0890-9369| pmid = 11274057 |doi = 10.1101/gad.191201 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=312660}}</ref><ref name=pmid11005803>{{Cita pubblicazione | quotes = yes |cognome=Clark |nome=A B |linkautore= |coautori=Valle F, Drotschmann K, Gary R K, Kunkel T A |anno=[[2000]]|mese=Nov. |titolo=Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes |rivista=J. Biol. Chem. |volume=275 |numero=47 |pagine=36498–501 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 11005803 |doi = 10.1074/jbc.C000513200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Werner syndrome ATP-dependent helicase]],<ref name=pmid12633936>{{Cita pubblicazione | quotes = yes |cognome=Rodríguez-López |nome=Ana M |linkautore= |coautori=Jackson Dean A, Nehlin Jan O, Iborra Francisco, Warren Anna V, Cox Lynne S |anno=[[2003]]|mese=Feb. |titolo=Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA |rivista=Mech. Ageing Dev. |volume=124 |numero=2 |pagine=167–74 |publisher= |___location = Ireland| issn = 0047-6374| pmid = 12633936 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S0047-6374(02)00131-8}}</ref><ref name=pmid10871373>{{Cita pubblicazione | quotes = yes |cognome=Huang |nome=S |linkautore= |coautori=Beresten S, Li B, Oshima J, Ellis N A, Campisi J |anno=[[2000]]|mese=Jun. |titolo=Characterization of the human and mouse WRN 3'-->5' exonuclease |rivista=Nucleic Acids Res. |volume=28 |numero=12 |pagine=2396–405 |publisher= |___location = ENGLAND| issn = | pmid = 10871373 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1093/nar/28.12.2396 | pmc=102739}}</ref> [[RFC2]],<ref name=pmid12171929/><ref name=pmid9228079>{{Cita pubblicazione | quotes = yes |cognome=Cai |nome=J |linkautore= |coautori=Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J |anno=[[1997]]|mese=Jul. |titolo=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme |rivista=J. Biol. Chem. |volume=272 |numero=30 |pagine=18974–81 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 9228079 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.272.30.18974}}</ref><ref name=pmid8093561>{{Cita pubblicazione | quotes = yes |cognome=Pan |nome=Z Q |linkautore= |coautori=Chen M, Hurwitz J |anno=[[1993]]|mese=Jan. |titolo=The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=90 |numero=1 |pagine=6–10 |publisher= |___location = UNITED STATES| issn = 0027-8424| pmid = 8093561 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1073/pnas.90.1.6 | pmc=45588}}</ref> [[RFC3]],<ref name=pmid12171929/><ref name=pmid12766176>{{Cita pubblicazione | quotes = yes |cognome=Merkle |nome=Carolin J |linkautore= |coautori=Karnitz Larry M, Henry-Sánchez John T, Chen Junjie |anno=[[2003]]|mese=Aug. |titolo=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment |rivista=J. Biol. Chem. |volume=278 |numero=32 |pagine=30051–6 |publisher= |___location = United States| issn = 0021-9258| pmid = 12766176 |doi = 10.1074/jbc.M211591200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RFC1]],<ref name=pmid12171929/><ref name=pmid12192049>{{Cita pubblicazione | quotes = yes |cognome=Maruyama |nome=Tetsuo |linkautore= |coautori=Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko |anno=[[2002]]|mese=Sep. |titolo=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase |rivista=Mol. Cell. Biol. |volume=22 |numero=18 |pagine=6509–20 |publisher= |___location = United States| issn = 0270-7306| pmid = 12192049 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1128/MCB.22.18.6509-6520.2002 | pmc=135621}}</ref><ref name=pmid8861969>{{Cita pubblicazione | quotes = yes |cognome=Fotedar |nome=R |linkautore= |coautori=Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A |anno=[[1996]]|mese=Aug. |titolo=A conserved ___domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells |rivista=EMBO J. |volume=15 |numero=16 |pagine=4423–33 |publisher= |___location = ENGLAND| issn = 0261-4189| pmid = 8861969 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=452166}}</ref><ref name=pmid8999859>{{Cita pubblicazione | quotes = yes |cognome=Mossi |nome=R |linkautore= |coautori=Jónsson Z O, Allen B L, Hardin S H, Hübscher U |anno=[[1997]]|mese=Jan. |titolo=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=272 |numero=3 |pagine=1769–76 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 8999859 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.272.3.1769}}</ref><ref name=pmid10353443>{{Cita pubblicazione | quotes = yes |cognome=van der Kuip |nome=H |linkautore= |coautori=Carius B, Haque S J, Williams B R, Huber C, Fischer T |anno=[[1999]]|mese=Apr. |titolo=The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins |rivista=J. Mol. Med. |volume=77 |numero=4 |pagine=386–92 |publisher= |___location = GERMANY| issn = 0946-2716| pmid = 10353443 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1007/s001090050365}}</ref> [[RFC4]],<ref name=pmid12171929/><ref name=pmid9228079/> [[RFC5]],<ref name=pmid12171929/><ref name=pmid9228079/><ref name=pmid8999859/> [[GADD45G]],<ref name=pmid11022036>{{Cita pubblicazione | quotes = yes |cognome=Azam |nome=N |linkautore= |coautori=Vairapandi M, Zhang W, Hoffman B, Liebermann D A |anno=[[2001]]|mese=Jan. |titolo=Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control |rivista=J. Biol. Chem. |volume=276 |numero=4 |pagine=2766–74 |publisher= |___location = United States| issn = 0021-9258| pmid = 11022036 |doi = 10.1074/jbc.M005626200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10455148>{{Cita pubblicazione | quotes = yes |cognome=Nakayama |nome=K |linkautore= |coautori=Hara T, Hibi M, Hirano T, Miyajima A |anno=[[1999]]|mese=Aug. |titolo=A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth |rivista=J. Biol. Chem. |volume=274 |numero=35 |pagine=24766–72 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10455148 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.274.35.24766}}</ref> [[CDC25C]],<ref name=pmid11896603>{{Cita pubblicazione | quotes = yes |cognome=Kawabe |nome=Takumi |linkautore= |coautori=Suganuma Masashi, Ando Tomoaki, Kimura Mayumi, Hori Haruna, Okamoto Takashi |anno=[[2002]]|mese=Mar. |titolo=Cdc25C interacts with PCNA at G2/M transition |rivista=Oncogene |volume=21 |numero=11 |pagine=1717–26 |publisher= |___location = England| issn = 0950-9232| pmid = 11896603 |doi = 10.1038/sj.onc.1205229 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MUTYH]],<ref name=pmid11092888>{{Cita pubblicazione | quotes = yes |cognome=Parker |nome=A |linkautore= |coautori=Gu Y, Mahoney W, Lee S H, Singh K K, Lu A L |anno=[[2001]]|mese=Feb. |titolo=Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair |rivista=J. Biol. Chem. |volume=276 |numero=8 |pagine=5547–55 |publisher= |___location = United States| issn = 0021-9258| pmid = 11092888 |doi = 10.1074/jbc.M008463200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Flap structure-specific endonuclease 1]],<ref name=pmid12853968>{{Cita pubblicazione | quotes = yes |cognome=Henneke |nome=Ghislaine |linkautore= |coautori=Koundrioukoff Stéphane, Hübscher Ulrich |anno=[[2003]]|mese=Jul. |titolo=Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation |rivista=Oncogene |volume=22 |numero=28 |pagine=4301–13 |publisher= |___location = England| issn = 0950-9232| pmid = 12853968 |doi = 10.1038/sj.onc.1206606 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11430825>{{Cita pubblicazione | quotes = yes |cognome=Hasan |nome=S |linkautore= |coautori=Stucki M, Hassa P O, Imhof R, Gehrig P, Hunziker P, Hübscher U, Hottiger M O |anno=[[2001]]|mese=Jun. |titolo=Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300 |rivista=Mol. Cell |volume=7 |numero=6 |pagine=1221–31 |publisher= |___location = United States| issn = 1097-2765| pmid = 11430825 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S1097-2765(01)00272-6}}</ref><ref name=pmid9545252>{{Cita pubblicazione | quotes = yes |cognome=Jónsson |nome=Z O |linkautore= |coautori=Hindges R, Hübscher U |anno=[[1998]]|mese=Apr. |titolo=Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen |rivista=EMBO J. |volume=17 |numero=8 |pagine=2412–25 |publisher= |___location = ENGLAND| issn = 0261-4189| pmid = 9545252 |doi = 10.1093/emboj/17.8.2412 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=1170584}}</ref><ref name=pmid9305916>{{Cita pubblicazione | quotes = yes |cognome=Gary |nome=R |linkautore= |coautori=Ludwig D L, Cornelius H L, MacInnes M A, Park M S |anno=[[1997]]|mese=Sep. |titolo=The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21 |rivista=J. Biol. Chem. |volume=272 |numero=39 |pagine=24522–9 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 9305916 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.272.39.24522}}</ref><ref name=pmid8876181>{{Cita pubblicazione | quotes = yes |cognome=Chen |nome=U |linkautore= |coautori=Chen S, Saha P, Dutta A |anno=[[1996]]|mese=Oct. |titolo=p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |numero=21 |pagine=11597–602 |publisher= |___location = UNITED STATES| issn = 0027-8424| pmid = 8876181 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1073/pnas.93.21.11597 | pmc=38103}}</ref><ref name=pmid11601988>{{Cita pubblicazione | quotes = yes |cognome=Dianova |nome=I I |linkautore= |coautori=Bohr V A, Dianov G L |anno=[[2001]]|mese=Oct. |titolo=Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair |rivista=Biochemistry |volume=40 |numero=42 |pagine=12639–44 |publisher= |___location = United States| issn = 0006-2960| pmid = 11601988 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1021/bi011117i}}</ref><ref name=pmid11313979>{{Cita pubblicazione | quotes = yes |cognome=Yu |nome=P |linkautore= |coautori=Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan D G, Luo Y |anno=[[2001]]|mese=Jan. |titolo=p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues |rivista=Oncogene |volume=20 |numero=4 |pagine=484–9 |publisher= |___location = England| issn = 0950-9232| pmid = 11313979 |doi = 10.1038/sj.onc.1204113 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin O]],<ref name=pmid12171929/><ref name=pmid10393198>{{Cita pubblicazione | quotes = yes |cognome=Otterlei |nome=M |linkautore= |coautori=Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E |anno=[[1999]]|mese=Jul. |titolo=Post-replicative base excision repair in replication foci |rivista=EMBO J. |volume=18 |numero=13 |pagine=3834–44 |publisher= |___location = ENGLAND| issn = 0261-4189| pmid = 10393198 |doi = 10.1093/emboj/18.13.3834 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=1171460}}</ref> [[CHTF18]],<ref name=pmid12171929/> [[Y box binding protein 1]],<ref name=pmid9927044>{{Cita pubblicazione | quotes = yes |cognome=Ise |nome=T |linkautore= |coautori=Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K |anno=[[1999]]|mese=Jan. |titolo=Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen |rivista=Cancer Res. |volume=59 |numero=2 |pagine=342–6 |publisher= |___location = UNITED STATES| issn = 0008-5472| pmid = 9927044 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin D1]],<ref name=pmid7908906>{{Cita pubblicazione | quotes = yes |cognome=Matsuoka |nome=S |linkautore= |coautori=Yamaguchi M, Matsukage A |anno=[[1994]]|mese=Apr. |titolo=D-type cyclin-binding regions of proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=269 |numero=15 |pagine=11030–6 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 7908906 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8101826>{{Cita pubblicazione | quotes = yes |cognome=Xiong |nome=Y |linkautore= |coautori=Zhang H, Beach D |anno=[[1993]]|mese=Aug. |titolo=Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation |rivista=Genes Dev. |volume=7 |numero=8 |pagine=1572–83 |publisher= |___location = UNITED STATES| issn = 0890-9369| pmid = 8101826 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1101/gad.7.8.1572}}</ref> [[Annexin A2]],<ref name=pmid12171929/> [[MSH6]],<ref name=pmid12171929/><ref name=pmid11274057/><ref name=pmid11005803/> [[DNMT1]],<ref name=pmid10888872>{{Cita pubblicazione | quotes = yes |cognome=Rountree |nome=M R |linkautore= |coautori=Bachman K E, Baylin S B |anno=[[2000]]|mese=Jul. |titolo=DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci |rivista=Nat. Genet. |volume=25 |numero=3 |pagine=269–77 |publisher= |___location = UNITED STATES| issn = 1061-4036| pmid = 10888872 |doi = 10.1038/77023 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12354094>{{Cita pubblicazione | quotes = yes |cognome=Iida |nome=Tetsuo |linkautore= |coautori=Suetake Isao, Tajima Shoji, Morioka Hiroshi, Ohta Satoshi, Obuse Chikashi, Tsurimoto Toshiki |anno=[[2002]]|mese=Oct. |titolo=PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA |rivista=Genes Cells |volume=7 |numero=10 |pagine=997–1007 |publisher= |___location = England| issn = 1356-9597| pmid = 12354094 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1046/j.1365-2443.2002.00584.x}}</ref><ref name=pmid9302295>{{Cita pubblicazione | quotes = yes |cognome=Chuang |nome=L S |linkautore= |coautori=Ian H I, Koh T W, Ng H H, Xu G, Li B F |anno=[[1997]]|mese=Sep. |titolo=Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1 |rivista=[[Science (journal)|Science]] |volume=277 |numero=5334 |pagine=1996–2000 |publisher= |___location = UNITED STATES| issn = 0036-8075| pmid = 9302295 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1126/science.277.5334.1996}}</ref> [[HDAC1]],<ref name=pmid11929879>{{Cita pubblicazione | quotes = yes |cognome=Milutinovic |nome=Snezana |linkautore= |coautori=Zhuang Qianli, Szyf Moshe |anno=[[2002]]|mese=Jun. |titolo=Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification |rivista=J. Biol. Chem. |volume=277 |numero=23 |pagine=20974–8 |publisher= |___location = United States| issn = 0021-9258| pmid = 11929879 |doi = 10.1074/jbc.M202504200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[KCTD13]],<ref name=pmid11593007>{{Cita pubblicazione | quotes = yes |cognome=He |nome=H |linkautore= |coautori=Tan C K, Downey K M, So A G |anno=[[2001]]|mese=Oct. |titolo=A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |numero=21 |pagine=11979–84 |publisher= |___location = United States| issn = 0027-8424| pmid = 11593007 |doi = 10.1073/pnas.221452098 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=59753}}</ref> [[XRCC1]],<ref name=pmid15107487>{{Cita pubblicazione | quotes = yes |cognome=Fan |nome=Jinshui |linkautore= |coautori=Otterlei Marit, Wong Heng-Kuan, Tomkinson Alan E, Wilson David M |anno=[[2004]]|mese= |titolo=XRCC1 co-localizes and physically interacts with PCNA |rivista=Nucleic Acids Res. |volume=32 |numero=7 |pagine=2193–201 |publisher= |___location = England| issn = | pmid = 15107487 |doi = 10.1093/nar/gkh556 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=407833}}</ref> [[Cyclin-dependent kinase 4]],<ref name=pmid8101826/><ref name=pmid8259215>{{Cita pubblicazione | quotes = yes |cognome=Serrano |nome=M |linkautore= |coautori=Hannon G J, Beach D |anno=[[1993]]|mese=Dec. |titolo=A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 |rivista=[[Nature (journal)|Nature]] |volume=366 |numero=6456 |pagine=704–7 |publisher= |___location = ENGLAND| issn = 0028-0836| pmid = 8259215| pmid = 8259207 |doi = 10.1038/366704a0 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Ku80]],<ref name=pmid12171929/><ref name=pmid11239001/><ref name=pmid12393188>{{Cita pubblicazione | quotes = yes |cognome=Matheos |nome=Diamanto |linkautore= |coautori=Ruiz Marcia T, Price Gerald B, Zannis-Hadjopoulos Maria |anno=[[2002]]|mese=Oct. |titolo=Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication |rivista=Biochim. Biophys. Acta |volume=1578 |numero=1-3 |pagine=59–72 |publisher= |___location = Netherlands| issn = 0006-3002| pmid = 12393188 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HUS1]],<ref name=pmid11077446>{{Cita pubblicazione | quotes = yes |cognome=Komatsu |nome=K |linkautore= |coautori=Wharton W, Hang H, Wu C, Singh S, Lieberman H B, Pledger W J, Wang H G |anno=[[2000]]|mese=Nov. |titolo=PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition |rivista=Oncogene |volume=19 |numero=46 |pagine=5291–7 |publisher= |___location = ENGLAND| issn = 0950-9232| pmid = 11077446 |doi = 10.1038/sj.onc.1203901 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GADD45A]],<ref name=pmid7973727>{{Cita pubblicazione | quotes = yes |cognome=Smith |nome=M L |linkautore= |coautori=Chen I T, Zhan Q, Bae I, Chen C Y, Gilmer T M, Kastan M B, O'Connor P M, Fornace A J |anno=[[1994]]|mese=Nov. |titolo=Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen |rivista=[[Science (journal)|Science]] |volume=266 |numero=5189 |pagine=1376–80 |publisher= |___location = UNITED STATES| issn = 0036-8075| pmid = 7973727| pmid = 7973719| pmid = 7481776| pmid = 7481777 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1126/science.7973727}}</ref><ref name=pmid7478510>{{Cita pubblicazione | quotes = yes |cognome=Chen |nome=I T |linkautore= |coautori=Smith M L, O'Connor P M, Fornace A J |anno=[[1995]]|mese=Nov. |titolo=Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA |rivista=Oncogene |volume=11 |numero=10 |pagine=1931–7 |publisher= |___location = ENGLAND| issn = 0950-9232| pmid = 7478510 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10828065>{{Cita pubblicazione | quotes = yes |cognome=Vairapandi |nome=M |linkautore= |coautori=Azam N, Balliet A G, Hoffman B, Liebermann D A |anno=[[2000]]|mese=Jun. |titolo=Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control |rivista=J. Biol. Chem. |volume=275 |numero=22 |pagine=16810–9 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10828065 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.275.22.16810}}</ref><ref name=pmid7784094>{{Cita pubblicazione | quotes = yes |cognome=Hall |nome=P A |linkautore= |coautori=Kearsey J M, Coates P J, Norman D G, Warbrick E, Cox L S |anno=[[1995]]|mese=Jun. |titolo=Characterisation of the interaction between PCNA and Gadd45 |rivista=Oncogene |volume=10 |numero=12 |pagine=2427–33 |publisher= |___location = ENGLAND| issn = 0950-9232| pmid = 7784094 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10973963>{{Cita pubblicazione | quotes = yes |cognome=Yang |nome=Q |linkautore= |coautori=Manicone A, Coursen J D, Linke S P, Nagashima M, Forgues M, Wang X W |anno=[[2000]]|mese=Nov. |titolo=Identification of a functional ___domain in a GADD45-mediated G2/M checkpoint |rivista=J. Biol. Chem. |volume=275 |numero=47 |pagine=36892–8 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10973963 |doi = 10.1074/jbc.M005319200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLD2]],<ref name=pmid11986310>{{Cita pubblicazione | quotes = yes |cognome=Lu |nome=Xiaoqing |linkautore= |coautori=Tan Cheng-Keat, Zhou Jin-Qiu, You Min, Carastro L Michael, Downey Kathleen M, So Antero G |anno=[[2002]]|mese=Jul. |titolo=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta |rivista=J. Biol. Chem. |volume=277 |numero=27 |pagine=24340–5 |publisher= |___location = United States| issn = 0021-9258| pmid = 11986310 |doi = 10.1074/jbc.M200065200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[ING1]],<ref name=pmid11682605>{{Cita pubblicazione | quotes = yes |cognome=Scott |nome=M |linkautore= |coautori=Bonnefin P, Vieyra D, Boisvert F M, Young D, Bazett-Jones D P, Riabowol K |anno=[[2001]]|mese=Oct. |titolo=UV-induced binding of ING1 to PCNA regulates the induction of apoptosis |rivista=J. Cell. Sci. |volume=114 |numero=Pt 19 |pagine=3455–62 |publisher= |___location = England| issn = 0021-9533| pmid = 11682605 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLH]],<ref name=pmid11585903>{{Cita pubblicazione | quotes = yes |cognome=Haracska |nome=L |linkautore= |coautori=Johnson R E, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S |anno=[[2001]]|mese=Nov. |titolo=Physical and functional interactions of human DNA polymerase eta with PCNA |rivista=Mol. Cell. Biol. |volume=21 |numero=21 |pagine=7199–206 |publisher= |___location = United States| issn = 0270-7306| pmid = 11585903 |doi = 10.1128/MCB.21.21.7199-7206.2001 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=99895}}</ref> [[KIAA0101]],<ref name=pmid11313979/> [[POLDIP2]],<ref name=pmid12522211>{{Cita pubblicazione | quotes = yes |cognome=Liu |nome=Li |linkautore= |coautori=Rodriguez-Belmonte Esther M, Mazloum Nayef, Xie Bin, Lee Marietta Y W T |anno=[[2003]]|mese=Mar. |titolo=Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=278 |numero=12 |pagine=10041–7 |publisher= |___location = United States| issn = 0021-9258| pmid = 12522211 |doi = 10.1074/jbc.M208694200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[EP300]],<ref name=pmid11268218>{{Cita pubblicazione | quotes = yes |cognome=Hasan |nome=S |linkautore= |coautori=Hassa P O, Imhof R, Hottiger M O |anno=[[2001]]|mese=Mar. |titolo=Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis |rivista=[[Nature (journal)|Nature]] |volume=410 |numero=6826 |pagine=387–91 |publisher= |___location = England| issn = 0028-0836| pmid = 11268218 |doi = 10.1038/35066610 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MCL1]],<ref name=pmid10978339>{{Cita pubblicazione | quotes = yes |cognome=Fujise |nome=K |linkautore= |coautori=Zhang D, Liu J, Yeh E T |anno=[[2000]]|mese=Dec. |titolo=Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=275 |numero=50 |pagine=39458–65 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10978339 |doi = 10.1074/jbc.M006626200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLD3]],<ref name=pmid12171929/><ref name=pmid11595739>{{Cita pubblicazione | quotes = yes |cognome=Ducoux |nome=M |linkautore= |coautori=Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P |anno=[[2001]]|mese=Dec. |titolo=Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta |rivista=J. Biol. Chem. |volume=276 |numero=52 |pagine=49258–66 |publisher= |___location = United States| issn = 0021-9258| pmid = 11595739 |doi = 10.1074/jbc.M106990200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin-dependent kinase inhibitor 1C]],<ref name=pmid9465025>{{Cita pubblicazione | quotes = yes |cognome=Watanabe |nome=H |linkautore= |coautori=Pan Z Q, Schreiber-Agus N, DePinho R A, Hurwitz J, Xiong Y |anno=[[1998]]|mese=Feb. |titolo=Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |numero=4 |pagine=1392–7 |publisher= |___location = UNITED STATES| issn = 0027-8424| pmid = 9465025 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1073/pnas.95.4.1392 | pmc=19016}}</ref> [[POLL]],<ref name=pmid11784855>{{Cita pubblicazione | quotes = yes |cognome=Haracska |nome=Lajos |linkautore= |coautori=Unk Ildiko, Johnson Robert E, Phillips Barbara B, Hurwitz Jerard, Prakash Louise, Prakash Satya |anno=[[2002]]|mese=Feb. |titolo=Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA |rivista=Mol. Cell. Biol. |volume=22 |numero=3 |pagine=784–91 |publisher= |___location = United States| issn = 0270-7306| pmid = 11784855 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1128/MCB.22.3.784-791.2002 | pmc=133560}}</ref><ref name=pmid12368291>{{Cita pubblicazione | quotes = yes |cognome=Maga |nome=Giovanni |linkautore= |coautori=Villani Giuseppe, Ramadan Kristijan, Shevelev Igor, Tanguy Le Gac Nicolas, Blanco Luis, Blanca Giuseppina, Spadari Silvio, Hübscher Ulrich |anno=[[2002]]|mese=Dec. |titolo=Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis |rivista=J. Biol. Chem. |volume=277 |numero=50 |pagine=48434–40 |publisher= |___location = United States| issn = 0021-9258| pmid = 12368291 |doi = 10.1074/jbc.M206889200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12081642>{{Cita pubblicazione | quotes = yes |cognome=Shimazaki |nome=Noriko |linkautore= |coautori=Yoshida Kenta, Kobayashi Toshiko, Toji Shingo, Tamai Katsuyuki, Koiwai Osamu |anno=[[2002]]|mese=Jul. |titolo=Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme |rivista=Genes Cells |volume=7 |numero=7 |pagine=639–51 |publisher= |___location = England| issn = 1356-9597| pmid = 12081642 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Ubiquitin C]]<ref name=pmid18719106>{{Cita pubblicazione | quotes = yes |cognome=Motegi |nome=Akira |linkautore= |coautori=Liaw Hung-Jiun, Lee Kyoo-Young, Roest Henk P, Maas Alex, Wu Xiaoli, Moinova Helen, Markowitz Sanford D, Ding Hao, Hoeijmakers Jan H J, Myung Kyungjae |anno=[[2008]]|mese=Aug. |titolo=Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=105 |numero=34 |pagine=12411–6 |publisher= |___location = United States| issn = | pmid = 18719106 |doi = 10.1073/pnas.0805685105 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=2518831}}</ref><ref name=pmid18316726>{{Cita pubblicazione | quotes = yes |cognome=Unk |nome=Ildiko |linkautore= |coautori=Hajdú Ildikó, Fátyol Károly, Hurwitz Jerard, Yoon Jung-Hoon, Prakash Louise, Prakash Satya, Haracska Lajos |anno=[[2008]]|mese=Mar. |titolo=Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=105 |numero=10 |pagine=3768–73 |publisher= |___location = United States| issn = | pmid = 18316726 |doi = 10.1073/pnas.0800563105 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=2268824}}</ref><ref name=pmid18284681>{{Cita pubblicazione | quotes = yes |cognome=Brun |nome=Jan |linkautore= |coautori=Chiu Roland, Lockhart Katherine, Xiao Wei, Wouters Bradly G, Gray Douglas A |anno=[[2008]]|mese= |titolo=hMMS2 serves a redundant role in human PCNA polyubiquitination |rivista=BMC Mol. Biol. |volume=9 |numero= |pagine=24 |publisher= |___location = England| issn = | pmid = 18284681 |doi = 10.1186/1471-2199-9-24 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=2263069}}</ref> and [[P21]].<ref name=pmid8861969/><ref name=pmid9545252/><ref name=pmid11313979/><ref name=pmid9465025/><ref name=pmid16189514>{{Cita pubblicazione | quotes = yes |cognome=Rual |nome=Jean-François |linkautore= |coautori=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |anno=[[2005]]|mese=Oct. |titolo=Towards a proteome-scale map of the human protein-protein interaction network |rivista=[[Nature (journal)|Nature]] |volume=437 |numero=7062 |pagine=1173–8 |publisher= |___location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12930846>{{Cita pubblicazione | quotes = yes |cognome=Frouin |nome=Isabelle |linkautore= |coautori=Maga Giovanni, Denegri Marco, Riva Federica, Savio Monica, Spadari Silvio, Prosperi Ennio, Scovassi A Ivana |anno=[[2003]]|mese=Oct. |titolo=Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners |rivista=J. Biol. Chem. |volume=278 |numero=41 |pagine=39265–8 |publisher= |___location = United States| issn = 0021-9258| pmid = 12930846 |doi = 10.1074/jbc.C300098200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8861913>{{Cita pubblicazione | quotes = yes |cognome=Gulbis |nome=J M |linkautore= |coautori=Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J |anno=[[1996]]|mese=Oct. |titolo=Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA |rivista=Cell |volume=87 |numero=2 |pagine=297–306 |publisher= |___location = UNITED STATES| issn = 0092-8674| pmid = 8861913 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S0092-8674(00)81347-1}}</ref><ref name=pmid11350925>{{Cita pubblicazione | quotes = yes |cognome=Touitou |nome=R |linkautore= |coautori=Richardson J, Bose S, Nakanishi M, Rivett J, Allday M J |anno=[[2001]]|mese=May. |titolo=A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome |rivista=EMBO J. |volume=20 |numero=10 |pagine=2367–75 |publisher= |___location = England| issn = 0261-4189| pmid = 11350925 |doi = 10.1093/emboj/20.10.2367 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=125454}}</ref>PCNA può interagire con: [[Ku70]],<ref name=pmid12171929>{{Cita pubblicazione | quotes = yes |cognome=Ohta |nome=Satoshi |linkautore= |coautori=Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki |anno=[[2002]]|mese=Oct. |titolo=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |rivista=J. Biol. Chem. |volume=277 |numero=43 |pagine=40362–7 |publisher= |___location = United States| issn = 0021-9258| id=PMID 12171929 |doi = 10.1074/jbc.M206194200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11239001>{{Cita pubblicazione | quotes = yes |cognome=Balajee |nome=A S |linkautore= |coautori=Geard C R |anno=[[2001]]|mese=Mar. |titolo=Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells |rivista=Nucleic Acids Res. |volume=29 |numero=6 |pagine=1341–51 |publisher= |___location = England| issn = | id=PMID 11239001 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1093/nar/29.6.1341 | pmc=29758}}</ref> [[MSH3]],<ref name=pmid12171929/><ref name=pmid11274057>{{Cita pubblicazione | quotes = yes |cognome=Kleczkowska |nome=H E |linkautore= |coautori=Marra G, Lettieri T, Jiricny J |anno=[[2001]]|mese=Mar. |titolo=hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci |rivista=Genes Dev. |volume=15 |numero=6 |pagine=724–36 |publisher= |___location = United States| issn = 0890-9369| id=PMID 11274057 |doi = 10.1101/gad.191201 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=312660}}</ref><ref name=pmid11005803>{{Cita pubblicazione | quotes = yes |cognome=Clark |nome=A B |linkautore= |coautori=Valle F, Drotschmann K, Gary R K, Kunkel T A |anno=[[2000]]|mese=Nov. |titolo=Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes |rivista=J. Biol. Chem. |volume=275 |numero=47 |pagine=36498–501 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 11005803 |doi = 10.1074/jbc.C000513200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Werner syndrome ATP-dependent helicase]],<ref name=pmid12633936>{{Cita pubblicazione | quotes = yes |cognome=Rodríguez-López |nome=Ana M |linkautore= |coautori=Jackson Dean A, Nehlin Jan O, Iborra Francisco, Warren Anna V, Cox Lynne S |anno=[[2003]]|mese=Feb. |titolo=Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA |rivista=Mech. Ageing Dev. |volume=124 |numero=2 |pagine=167–74 |publisher= |___location = Ireland| issn = 0047-6374| id=PMID 12633936 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S0047-6374(02)00131-8}}</ref><ref name=pmid10871373>{{Cita pubblicazione | quotes = yes |cognome=Huang |nome=S |linkautore= |coautori=Beresten S, Li B, Oshima J, Ellis N A, Campisi J |anno=[[2000]]|mese=Jun. |titolo=Characterization of the human and mouse WRN 3'-->5' exonuclease |rivista=Nucleic Acids Res. |volume=28 |numero=12 |pagine=2396–405 |publisher= |___location = ENGLAND| issn = | id=PMID 10871373 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1093/nar/28.12.2396 | pmc=102739}}</ref> [[RFC2]],<ref name=pmid12171929/><ref name=pmid9228079>{{Cita pubblicazione | quotes = yes |cognome=Cai |nome=J |linkautore= |coautori=Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J |anno=[[1997]]|mese=Jul. |titolo=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme |rivista=J. Biol. Chem. |volume=272 |numero=30 |pagine=18974–81 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 9228079 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.272.30.18974}}</ref><ref name=pmid8093561>{{Cita pubblicazione | quotes = yes |cognome=Pan |nome=Z Q |linkautore= |coautori=Chen M, Hurwitz J |anno=[[1993]]|mese=Jan. |titolo=The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=90 |numero=1 |pagine=6–10 |publisher= |___location = UNITED STATES| issn = 0027-8424| id=PMID 8093561 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1073/pnas.90.1.6 | pmc=45588}}</ref> [[RFC3]],<ref name=pmid12171929/><ref name=pmid12766176>{{Cita pubblicazione | quotes = yes |cognome=Merkle |nome=Carolin J |linkautore= |coautori=Karnitz Larry M, Henry-Sánchez John T, Chen Junjie |anno=[[2003]]|mese=Aug. |titolo=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment |rivista=J. Biol. Chem. |volume=278 |numero=32 |pagine=30051–6 |publisher= |___location = United States| issn = 0021-9258| id=PMID 12766176 |doi = 10.1074/jbc.M211591200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RFC1]],<ref name=pmid12171929/><ref name=pmid12192049>{{Cita pubblicazione | quotes = yes |cognome=Maruyama |nome=Tetsuo |linkautore= |coautori=Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko |anno=[[2002]]|mese=Sep. |titolo=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase |rivista=Mol. Cell. Biol. |volume=22 |numero=18 |pagine=6509–20 |publisher= |___location = United States| issn = 0270-7306| id=PMID 12192049 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1128/MCB.22.18.6509-6520.2002 | pmc=135621}}</ref><ref name=pmid8861969>{{Cita pubblicazione | quotes = yes |cognome=Fotedar |nome=R |linkautore= |coautori=Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A |anno=[[1996]]|mese=Aug. |titolo=A conserved ___domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells |rivista=EMBO J. |volume=15 |numero=16 |pagine=4423–33 |publisher= |___location = ENGLAND| issn = 0261-4189| id=PMID 8861969 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=452166}}</ref><ref name=pmid8999859>{{Cita pubblicazione | quotes = yes |cognome=Mossi |nome=R |linkautore= |coautori=Jónsson Z O, Allen B L, Hardin S H, Hübscher U |anno=[[1997]]|mese=Jan. |titolo=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=272 |numero=3 |pagine=1769–76 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 8999859 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.272.3.1769}}</ref><ref name=pmid10353443>{{Cita pubblicazione | quotes = yes |cognome=van der Kuip |nome=H |linkautore= |coautori=Carius B, Haque S J, Williams B R, Huber C, Fischer T |anno=[[1999]]|mese=Apr. |titolo=The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins |rivista=J. Mol. Med. |volume=77 |numero=4 |pagine=386–92 |publisher= |___location = GERMANY| issn = 0946-2716| id=PMID 10353443 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1007/s001090050365}}</ref> [[RFC4]],<ref name=pmid12171929/><ref name=pmid9228079/> [[RFC5]],<ref name=pmid12171929/><ref name=pmid9228079/><ref name=pmid8999859/> [[GADD45G]],<ref name=pmid11022036>{{Cita pubblicazione | quotes = yes |cognome=Azam |nome=N |linkautore= |coautori=Vairapandi M, Zhang W, Hoffman B, Liebermann D A |anno=[[2001]]|mese=Jan. |titolo=Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control |rivista=J. Biol. Chem. |volume=276 |numero=4 |pagine=2766–74 |publisher= |___location = United States| issn = 0021-9258| id=PMID 11022036 |doi = 10.1074/jbc.M005626200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10455148>{{Cita pubblicazione | quotes = yes |cognome=Nakayama |nome=K |linkautore= |coautori=Hara T, Hibi M, Hirano T, Miyajima A |anno=[[1999]]|mese=Aug. |titolo=A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth |rivista=J. Biol. Chem. |volume=274 |numero=35 |pagine=24766–72 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 10455148 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.274.35.24766}}</ref> [[CDC25C]],<ref name=pmid11896603>{{Cita pubblicazione | quotes = yes |cognome=Kawabe |nome=Takumi |linkautore= |coautori=Suganuma Masashi, Ando Tomoaki, Kimura Mayumi, Hori Haruna, Okamoto Takashi |anno=[[2002]]|mese=Mar. |titolo=Cdc25C interacts with PCNA at G2/M transition |rivista=Oncogene |volume=21 |numero=11 |pagine=1717–26 |publisher= |___location = England| issn = 0950-9232| id=PMID 11896603 |doi = 10.1038/sj.onc.1205229 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MUTYH]],<ref name=pmid11092888>{{Cita pubblicazione | quotes = yes |cognome=Parker |nome=A |linkautore= |coautori=Gu Y, Mahoney W, Lee S H, Singh K K, Lu A L |anno=[[2001]]|mese=Feb. |titolo=Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair |rivista=J. Biol. Chem. |volume=276 |numero=8 |pagine=5547–55 |publisher= |___location = United States| issn = 0021-9258| id=PMID 11092888 |doi = 10.1074/jbc.M008463200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Flap structure-specific endonuclease 1]],<ref name=pmid12853968>{{Cita pubblicazione | quotes = yes |cognome=Henneke |nome=Ghislaine |linkautore= |coautori=Koundrioukoff Stéphane, Hübscher Ulrich |anno=[[2003]]|mese=Jul. |titolo=Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation |rivista=Oncogene |volume=22 |numero=28 |pagine=4301–13 |publisher= |___location = England| issn = 0950-9232| id=PMID 12853968 |doi = 10.1038/sj.onc.1206606 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11430825>{{Cita pubblicazione | quotes = yes |cognome=Hasan |nome=S |linkautore= |coautori=Stucki M, Hassa P O, Imhof R, Gehrig P, Hunziker P, Hübscher U, Hottiger M O |anno=[[2001]]|mese=Jun. |titolo=Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300 |rivista=Mol. Cell |volume=7 |numero=6 |pagine=1221–31 |publisher= |___location = United States| issn = 1097-2765| id=PMID 11430825 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S1097-2765(01)00272-6}}</ref><ref name=pmid9545252>{{Cita pubblicazione | quotes = yes |cognome=Jónsson |nome=Z O |linkautore= |coautori=Hindges R, Hübscher U |anno=[[1998]]|mese=Apr. |titolo=Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen |rivista=EMBO J. |volume=17 |numero=8 |pagine=2412–25 |publisher= |___location = ENGLAND| issn = 0261-4189| id=PMID 9545252 |doi = 10.1093/emboj/17.8.2412 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=1170584}}</ref><ref name=pmid9305916>{{Cita pubblicazione | quotes = yes |cognome=Gary |nome=R |linkautore= |coautori=Ludwig D L, Cornelius H L, MacInnes M A, Park M S |anno=[[1997]]|mese=Sep. |titolo=The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21 |rivista=J. Biol. Chem. |volume=272 |numero=39 |pagine=24522–9 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 9305916 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.272.39.24522}}</ref><ref name=pmid8876181>{{Cita pubblicazione | quotes = yes |cognome=Chen |nome=U |linkautore= |coautori=Chen S, Saha P, Dutta A |anno=[[1996]]|mese=Oct. |titolo=p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |numero=21 |pagine=11597–602 |publisher= |___location = UNITED STATES| issn = 0027-8424| id=PMID 8876181 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1073/pnas.93.21.11597 | pmc=38103}}</ref><ref name=pmid11601988>{{Cita pubblicazione | quotes = yes |cognome=Dianova |nome=I I |linkautore= |coautori=Bohr V A, Dianov G L |anno=[[2001]]|mese=Oct. |titolo=Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair |rivista=Biochemistry |volume=40 |numero=42 |pagine=12639–44 |publisher= |___location = United States| issn = 0006-2960| id=PMID 11601988 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1021/bi011117i}}</ref><ref name=pmid11313979>{{Cita pubblicazione | quotes = yes |cognome=Yu |nome=P |linkautore= |coautori=Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan D G, Luo Y |anno=[[2001]]|mese=Jan. |titolo=p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues |rivista=Oncogene |volume=20 |numero=4 |pagine=484–9 |publisher= |___location = England| issn = 0950-9232| id=PMID 11313979 |doi = 10.1038/sj.onc.1204113 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin O]],<ref name=pmid12171929/><ref name=pmid10393198>{{Cita pubblicazione | quotes = yes |cognome=Otterlei |nome=M |linkautore= |coautori=Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E |anno=[[1999]]|mese=Jul. |titolo=Post-replicative base excision repair in replication foci |rivista=EMBO J. |volume=18 |numero=13 |pagine=3834–44 |publisher= |___location = ENGLAND| issn = 0261-4189| id=PMID 10393198 |doi = 10.1093/emboj/18.13.3834 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=1171460}}</ref> [[CHTF18]],<ref name=pmid12171929/> [[Y box binding protein 1]],<ref name=pmid9927044>{{Cita pubblicazione | quotes = yes |cognome=Ise |nome=T |linkautore= |coautori=Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K |anno=[[1999]]|mese=Jan. |titolo=Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen |rivista=Cancer Res. |volume=59 |numero=2 |pagine=342–6 |publisher= |___location = UNITED STATES| issn = 0008-5472| id=PMID 9927044 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin D1]],<ref name=pmid7908906>{{Cita pubblicazione | quotes = yes |cognome=Matsuoka |nome=S |linkautore= |coautori=Yamaguchi M, Matsukage A |anno=[[1994]]|mese=Apr. |titolo=D-type cyclin-binding regions of proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=269 |numero=15 |pagine=11030–6 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 7908906 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8101826>{{Cita pubblicazione | quotes = yes |cognome=Xiong |nome=Y |linkautore= |coautori=Zhang H, Beach D |anno=[[1993]]|mese=Aug. |titolo=Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation |rivista=Genes Dev. |volume=7 |numero=8 |pagine=1572–83 |publisher= |___location = UNITED STATES| issn = 0890-9369| id=PMID 8101826 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1101/gad.7.8.1572}}</ref> [[Annexin A2]],<ref name=pmid12171929/> [[MSH6]],<ref name=pmid12171929/><ref name=pmid11274057/><ref name=pmid11005803/> [[DNMT1]],<ref name=pmid10888872>{{Cita pubblicazione | quotes = yes |cognome=Rountree |nome=M R |linkautore= |coautori=Bachman K E, Baylin S B |anno=[[2000]]|mese=Jul. |titolo=DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci |rivista=Nat. Genet. |volume=25 |numero=3 |pagine=269–77 |publisher= |___location = UNITED STATES| issn = 1061-4036| id=PMID 10888872 |doi = 10.1038/77023 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12354094>{{Cita pubblicazione | quotes = yes |cognome=Iida |nome=Tetsuo |linkautore= |coautori=Suetake Isao, Tajima Shoji, Morioka Hiroshi, Ohta Satoshi, Obuse Chikashi, Tsurimoto Toshiki |anno=[[2002]]|mese=Oct. |titolo=PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA |rivista=Genes Cells |volume=7 |numero=10 |pagine=997–1007 |publisher= |___location = England| issn = 1356-9597| id=PMID 12354094 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1046/j.1365-2443.2002.00584.x}}</ref><ref name=pmid9302295>{{Cita pubblicazione | quotes = yes |cognome=Chuang |nome=L S |linkautore= |coautori=Ian H I, Koh T W, Ng H H, Xu G, Li B F |anno=[[1997]]|mese=Sep. |titolo=Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1 |rivista=[[Science (journal)|Science]] |volume=277 |numero=5334 |pagine=1996–2000 |publisher= |___location = UNITED STATES| issn = 0036-8075| id=PMID 9302295 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1126/science.277.5334.1996}}</ref> [[HDAC1]],<ref name=pmid11929879>{{Cita pubblicazione | quotes = yes |cognome=Milutinovic |nome=Snezana |linkautore= |coautori=Zhuang Qianli, Szyf Moshe |anno=[[2002]]|mese=Jun. |titolo=Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification |rivista=J. Biol. Chem. |volume=277 |numero=23 |pagine=20974–8 |publisher= |___location = United States| issn = 0021-9258| id=PMID 11929879 |doi = 10.1074/jbc.M202504200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[KCTD13]],<ref name=pmid11593007>{{Cita pubblicazione | quotes = yes |cognome=He |nome=H |linkautore= |coautori=Tan C K, Downey K M, So A G |anno=[[2001]]|mese=Oct. |titolo=A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |numero=21 |pagine=11979–84 |publisher= |___location = United States| issn = 0027-8424| id=PMID 11593007 |doi = 10.1073/pnas.221452098 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=59753}}</ref> [[XRCC1]],<ref name=pmid15107487>{{Cita pubblicazione | quotes = yes |cognome=Fan |nome=Jinshui |linkautore= |coautori=Otterlei Marit, Wong Heng-Kuan, Tomkinson Alan E, Wilson David M |anno=[[2004]]|mese= |titolo=XRCC1 co-localizes and physically interacts with PCNA |rivista=Nucleic Acids Res. |volume=32 |numero=7 |pagine=2193–201 |publisher= |___location = England| issn = | id=PMID 15107487 |doi = 10.1093/nar/gkh556 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=407833}}</ref> [[Cyclin-dependent kinase 4]],<ref name=pmid8101826/><ref name=pmid8259215>{{Cita pubblicazione | quotes = yes |cognome=Serrano |nome=M |linkautore= |coautori=Hannon G J, Beach D |anno=[[1993]]|mese=Dec. |titolo=A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 |rivista=[[Nature (journal)|Nature]] |volume=366 |numero=6456 |pagine=704–7 |publisher= |___location = ENGLAND| issn = 0028-0836| id=PMID 8259215| id=PMID 8259207 |doi = 10.1038/366704a0 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Ku80]],<ref name=pmid12171929/><ref name=pmid11239001/><ref name=pmid12393188>{{Cita pubblicazione | quotes = yes |cognome=Matheos |nome=Diamanto |linkautore= |coautori=Ruiz Marcia T, Price Gerald B, Zannis-Hadjopoulos Maria |anno=[[2002]]|mese=Oct. |titolo=Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication |rivista=Biochim. Biophys. Acta |volume=1578 |numero=1-3 |pagine=59–72 |publisher= |___location = Netherlands| issn = 0006-3002| id=PMID 12393188 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HUS1]],<ref name=pmid11077446>{{Cita pubblicazione | quotes = yes |cognome=Komatsu |nome=K |linkautore= |coautori=Wharton W, Hang H, Wu C, Singh S, Lieberman H B, Pledger W J, Wang H G |anno=[[2000]]|mese=Nov. |titolo=PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition |rivista=Oncogene |volume=19 |numero=46 |pagine=5291–7 |publisher= |___location = ENGLAND| issn = 0950-9232| id=PMID 11077446 |doi = 10.1038/sj.onc.1203901 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GADD45A]],<ref name=pmid7973727>{{Cita pubblicazione | quotes = yes |cognome=Smith |nome=M L |linkautore= |coautori=Chen I T, Zhan Q, Bae I, Chen C Y, Gilmer T M, Kastan M B, O'Connor P M, Fornace A J |anno=[[1994]]|mese=Nov. |titolo=Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen |rivista=[[Science (journal)|Science]] |volume=266 |numero=5189 |pagine=1376–80 |publisher= |___location = UNITED STATES| issn = 0036-8075| id=PMID 7973727| id=PMID 7973719| id=PMID 7481776| id=PMID 7481777 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1126/science.7973727}}</ref><ref name=pmid7478510>{{Cita pubblicazione | quotes = yes |cognome=Chen |nome=I T |linkautore= |coautori=Smith M L, O'Connor P M, Fornace A J |anno=[[1995]]|mese=Nov. |titolo=Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA |rivista=Oncogene |volume=11 |numero=10 |pagine=1931–7 |publisher= |___location = ENGLAND| issn = 0950-9232| id=PMID 7478510 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10828065>{{Cita pubblicazione | quotes = yes |cognome=Vairapandi |nome=M |linkautore= |coautori=Azam N, Balliet A G, Hoffman B, Liebermann D A |anno=[[2000]]|mese=Jun. |titolo=Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control |rivista=J. Biol. Chem. |volume=275 |numero=22 |pagine=16810–9 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 10828065 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1074/jbc.275.22.16810}}</ref><ref name=pmid7784094>{{Cita pubblicazione | quotes = yes |cognome=Hall |nome=P A |linkautore= |coautori=Kearsey J M, Coates P J, Norman D G, Warbrick E, Cox L S |anno=[[1995]]|mese=Jun. |titolo=Characterisation of the interaction between PCNA and Gadd45 |rivista=Oncogene |volume=10 |numero=12 |pagine=2427–33 |publisher= |___location = ENGLAND| issn = 0950-9232| id=PMID 7784094 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10973963>{{Cita pubblicazione | quotes = yes |cognome=Yang |nome=Q |linkautore= |coautori=Manicone A, Coursen J D, Linke S P, Nagashima M, Forgues M, Wang X W |anno=[[2000]]|mese=Nov. |titolo=Identification of a functional ___domain in a GADD45-mediated G2/M checkpoint |rivista=J. Biol. Chem. |volume=275 |numero=47 |pagine=36892–8 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 10973963 |doi = 10.1074/jbc.M005319200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLD2]],<ref name=pmid11986310>{{Cita pubblicazione | quotes = yes |cognome=Lu |nome=Xiaoqing |linkautore= |coautori=Tan Cheng-Keat, Zhou Jin-Qiu, You Min, Carastro L Michael, Downey Kathleen M, So Antero G |anno=[[2002]]|mese=Jul. |titolo=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta |rivista=J. Biol. Chem. |volume=277 |numero=27 |pagine=24340–5 |publisher= |___location = United States| issn = 0021-9258| id=PMID 11986310 |doi = 10.1074/jbc.M200065200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[ING1]],<ref name=pmid11682605>{{Cita pubblicazione | quotes = yes |cognome=Scott |nome=M |linkautore= |coautori=Bonnefin P, Vieyra D, Boisvert F M, Young D, Bazett-Jones D P, Riabowol K |anno=[[2001]]|mese=Oct. |titolo=UV-induced binding of ING1 to PCNA regulates the induction of apoptosis |rivista=J. Cell. Sci. |volume=114 |numero=Pt 19 |pagine=3455–62 |publisher= |___location = England| issn = 0021-9533| id=PMID 11682605 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLH]],<ref name=pmid11585903>{{Cita pubblicazione | quotes = yes |cognome=Haracska |nome=L |linkautore= |coautori=Johnson R E, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S |anno=[[2001]]|mese=Nov. |titolo=Physical and functional interactions of human DNA polymerase eta with PCNA |rivista=Mol. Cell. Biol. |volume=21 |numero=21 |pagine=7199–206 |publisher= |___location = United States| issn = 0270-7306| id=PMID 11585903 |doi = 10.1128/MCB.21.21.7199-7206.2001 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=99895}}</ref> [[KIAA0101]],<ref name=pmid11313979/> [[POLDIP2]],<ref name=pmid12522211>{{Cita pubblicazione | quotes = yes |cognome=Liu |nome=Li |linkautore= |coautori=Rodriguez-Belmonte Esther M, Mazloum Nayef, Xie Bin, Lee Marietta Y W T |anno=[[2003]]|mese=Mar. |titolo=Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=278 |numero=12 |pagine=10041–7 |publisher= |___location = United States| issn = 0021-9258| id=PMID 12522211 |doi = 10.1074/jbc.M208694200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[EP300]],<ref name=pmid11268218>{{Cita pubblicazione | quotes = yes |cognome=Hasan |nome=S |linkautore= |coautori=Hassa P O, Imhof R, Hottiger M O |anno=[[2001]]|mese=Mar. |titolo=Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis |rivista=[[Nature (journal)|Nature]] |volume=410 |numero=6826 |pagine=387–91 |publisher= |___location = England| issn = 0028-0836| id=PMID 11268218 |doi = 10.1038/35066610 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MCL1]],<ref name=pmid10978339>{{Cita pubblicazione | quotes = yes |cognome=Fujise |nome=K |linkautore= |coautori=Zhang D, Liu J, Yeh E T |anno=[[2000]]|mese=Dec. |titolo=Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen |rivista=J. Biol. Chem. |volume=275 |numero=50 |pagine=39458–65 |publisher= |___location = UNITED STATES| issn = 0021-9258| id=PMID 10978339 |doi = 10.1074/jbc.M006626200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLD3]],<ref name=pmid12171929/><ref name=pmid11595739>{{Cita pubblicazione | quotes = yes |cognome=Ducoux |nome=M |linkautore= |coautori=Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P |anno=[[2001]]|mese=Dec. |titolo=Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta |rivista=J. Biol. Chem. |volume=276 |numero=52 |pagine=49258–66 |publisher= |___location = United States| issn = 0021-9258| id=PMID 11595739 |doi = 10.1074/jbc.M106990200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Cyclin-dependent kinase inhibitor 1C]],<ref name=pmid9465025>{{Cita pubblicazione | quotes = yes |cognome=Watanabe |nome=H |linkautore= |coautori=Pan Z Q, Schreiber-Agus N, DePinho R A, Hurwitz J, Xiong Y |anno=[[1998]]|mese=Feb. |titolo=Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |numero=4 |pagine=1392–7 |publisher= |___location = UNITED STATES| issn = 0027-8424| id=PMID 9465025 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1073/pnas.95.4.1392 | pmc=19016}}</ref> [[POLL]],<ref name=pmid11784855>{{Cita pubblicazione | quotes = yes |cognome=Haracska |nome=Lajos |linkautore= |coautori=Unk Ildiko, Johnson Robert E, Phillips Barbara B, Hurwitz Jerard, Prakash Louise, Prakash Satya |anno=[[2002]]|mese=Feb. |titolo=Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA |rivista=Mol. Cell. Biol. |volume=22 |numero=3 |pagine=784–91 |publisher= |___location = United States| issn = 0270-7306| id=PMID 11784855 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1128/MCB.22.3.784-791.2002 | pmc=133560}}</ref><ref name=pmid12368291>{{Cita pubblicazione | quotes = yes |cognome=Maga |nome=Giovanni |linkautore= |coautori=Villani Giuseppe, Ramadan Kristijan, Shevelev Igor, Tanguy Le Gac Nicolas, Blanco Luis, Blanca Giuseppina, Spadari Silvio, Hübscher Ulrich |anno=[[2002]]|mese=Dec. |titolo=Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis |rivista=J. Biol. Chem. |volume=277 |numero=50 |pagine=48434–40 |publisher= |___location = United States| issn = 0021-9258| id=PMID 12368291 |doi = 10.1074/jbc.M206889200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12081642>{{Cita pubblicazione | quotes = yes |cognome=Shimazaki |nome=Noriko |linkautore= |coautori=Yoshida Kenta, Kobayashi Toshiko, Toji Shingo, Tamai Katsuyuki, Koiwai Osamu |anno=[[2002]]|mese=Jul. |titolo=Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme |rivista=Genes Cells |volume=7 |numero=7 |pagine=639–51 |publisher= |___location = England| issn = 1356-9597| id=PMID 12081642 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Ubiquitin C]]<ref name=pmid18719106>{{Cita pubblicazione | quotes = yes |cognome=Motegi |nome=Akira |linkautore= |coautori=Liaw Hung-Jiun, Lee Kyoo-Young, Roest Henk P, Maas Alex, Wu Xiaoli, Moinova Helen, Markowitz Sanford D, Ding Hao, Hoeijmakers Jan H J, Myung Kyungjae |anno=[[2008]]|mese=Aug. |titolo=Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=105 |numero=34 |pagine=12411–6 |publisher= |___location = United States| issn = | id=PMID 18719106 |doi = 10.1073/pnas.0805685105 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=2518831}}</ref><ref name=pmid18316726>{{Cita pubblicazione | quotes = yes |cognome=Unk |nome=Ildiko |linkautore= |coautori=Hajdú Ildikó, Fátyol Károly, Hurwitz Jerard, Yoon Jung-Hoon, Prakash Louise, Prakash Satya, Haracska Lajos |anno=[[2008]]|mese=Mar. |titolo=Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination |rivista=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=105 |numero=10 |pagine=3768–73 |publisher= |___location = United States| issn = | id=PMID 18316726 |doi = 10.1073/pnas.0800563105 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=2268824}}</ref><ref name=pmid18284681>{{Cita pubblicazione | quotes = yes |cognome=Brun |nome=Jan |linkautore= |coautori=Chiu Roland, Lockhart Katherine, Xiao Wei, Wouters Bradly G, Gray Douglas A |anno=[[2008]]|mese= |titolo=hMMS2 serves a redundant role in human PCNA polyubiquitination |rivista=BMC Mol. Biol. |volume=9 |numero= |pagine=24 |publisher= |___location = England| issn = | id=PMID 18284681 |doi = 10.1186/1471-2199-9-24 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=2263069}}</ref> and [[P21]].<ref name=pmid8861969/><ref name=pmid9545252/><ref name=pmid11313979/><ref name=pmid9465025/><ref name=pmid16189514>{{Cita pubblicazione | quotes = yes |cognome=Rual |nome=Jean-François |linkautore= |coautori=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |anno=[[2005]]|mese=Oct. |titolo=Towards a proteome-scale map of the human protein-protein interaction network |rivista=[[Nature (journal)|Nature]] |volume=437 |numero=7062 |pagine=1173–8 |publisher= |___location = England| issn = | id=PMID 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12930846>{{Cita pubblicazione | quotes = yes |cognome=Frouin |nome=Isabelle |linkautore= |coautori=Maga Giovanni, Denegri Marco, Riva Federica, Savio Monica, Spadari Silvio, Prosperi Ennio, Scovassi A Ivana |anno=[[2003]]|mese=Oct. |titolo=Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners |rivista=J. Biol. Chem. |volume=278 |numero=41 |pagine=39265–8 |publisher= |___location = United States| issn = 0021-9258| id=PMID 12930846 |doi = 10.1074/jbc.C300098200 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8861913>{{Cita pubblicazione | quotes = yes |cognome=Gulbis |nome=J M |linkautore= |coautori=Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J |anno=[[1996]]|mese=Oct. |titolo=Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA |rivista=Cell |volume=87 |numero=2 |pagine=297–306 |publisher= |___location = UNITED STATES| issn = 0092-8674| id=PMID 8861913 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S0092-8674(00)81347-1}}</ref><ref name=pmid11350925>{{Cita pubblicazione | quotes = yes |cognome=Touitou |nome=R |linkautore= |coautori=Richardson J, Bose S, Nakanishi M, Rivett J, Allday M J |anno=[[2001]]|mese=May. |titolo=A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome |rivista=EMBO J. |volume=20 |numero=10 |pagine=2367–75 |publisher= |___location = England| issn = 0261-4189| id=PMID 11350925 |doi = 10.1093/emboj/20.10.2367 | bibcode = | oclc =| id = | url = | lingua = | format = | accesso = | laysummary = | laysource = | laydate = | quote = | pmc=125454}}</ref>
==Note==
==Bibliografia==
* {{Cita pubblicazione | autore=Prosperi E |titolo=Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control. |rivista=Progress in cell cycle research |volume=3 |numero= |pagine= 193–210 |anno= 1998 |pmidid=PMID 9552415 |doi= }}
* {{Cita pubblicazione | autore=Miura M |titolo=Detection of chromatin-bound PCNA in mammalian cells and its use to study DNA excision repair. |rivista=J. Radiat. Res. |volume=40 |numero= 1 |pagine= 1–12 |anno= 1999 |pmidid=PMID 10408173 |doi=10.1269/jrr.40.1 }}
* {{Cita pubblicazione | autore=Chen M, Pan ZQ, Hurwitz J |titolo=Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. |rivista=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |numero= 7 |pagine= 2516–20 |anno= 1992 |pmidid=PMID 1313560 |doi=10.1073/pnas.89.7.2516 |pmc=48692}}
* {{Cita pubblicazione | autore=Kemeny MM, Alava G, Oliver JM |titolo=Improving responses in hepatomas with circadian-patterned hepatic artery infusions of recombinant interleukin-2. |rivista=J. Immunother. |volume=12 |numero= 4 |pagine= 219–23 |anno= 1993 |pmidid=PMID 1477073 |doi=10.1097/00002371-199211000-00001 }}
* {{Cita pubblicazione | autore=Morris GF, Mathews MB |titolo=Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1. |rivista=J. Biol. Chem. |volume=265 |numero= 27 |pagine= 16116–25 |anno= 1990 |pmidid=PMID 1975809 |doi= }}
* {{Cita pubblicazione | autore=Webb G, Parsons P, Chenevix-Trench G |titolo=Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization. |rivista=Hum. Genet. |volume=86 |numero= 1 |pagine= 84–6 |anno= 1991 |pmidid=PMID 1979311 |doi= }}
* {{Cita pubblicazione | autore=Travali S, Ku DH, Rizzo MG, ''et al.'' |titolo=Structure of the human gene for the proliferating cell nuclear antigen. |rivista=J. Biol. Chem. |volume=264 |numero= 13 |pagine= 7466–72 |anno= 1989 |pmidid=PMID 2565339 |doi= }}
* {{Cita pubblicazione | autore=Ku DH, Travali S, Calabretta B, ''et al.'' |titolo=Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20. |rivista=Somat. Cell Mol. Genet. |volume=15 |numero= 4 |pagine= 297–307 |anno= 1989 |pmidid=PMID 2569765 |doi=10.1007/BF01534969 }}
* {{Cita pubblicazione | autore=Prelich G, Kostura M, Marshak DR, ''et al.'' |titolo=The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro. |rivista=Nature |volume=326 |numero= 6112 |pagine= 471–5 |anno= 1987 |pmidid=PMID 2882422 |doi= 10.1038/326471a0 }}
* {{Cita pubblicazione | autore=Almendral JM, Huebsch D, Blundell PA, ''et al.'' |titolo=Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins. |rivista=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |numero= 6 |pagine= 1575–9 |anno= 1987 |pmidid=PMID 2882507 |doi=10.1073/pnas.84.6.1575 }}
* {{Cita pubblicazione | autore=Chen IT, Smith ML, O'Connor PM, Fornace AJ |titolo=Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. |rivista=Oncogene |volume=11 |numero= 10 |pagine= 1931–7 |anno= 1995 |pmidid=PMID 7478510 |doi= }}
* {{Cita pubblicazione | autore=Li X, Li J, Harrington J, ''et al.'' |titolo=Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. |rivista=J. Biol. Chem. |volume=270 |numero= 38 |pagine= 22109–12 |anno= 1995 |pmidid=PMID 7673186 |doi=10.1074/jbc.270.38.22109 }}
* {{Cita pubblicazione | autore=Fukuda K, Morioka H, Imajou S, ''et al.'' |titolo=Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen. |rivista=J. Biol. Chem. |volume=270 |numero= 38 |pagine= 22527–34 |anno= 1995 |pmidid=PMID 7673244 |doi=10.1074/jbc.270.38.22527 }}
* {{Cita pubblicazione | autore=Warbrick E, Lane DP, Glover DM, Cox LS |titolo=A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. |rivista=Curr. Biol. |volume=5 |numero= 3 |pagine= 275–82 |anno= 1995 |pmidid=PMID 7780738 |doi=10.1016/S0960-9822(95)00058-3 }}
* {{Cita pubblicazione | autore=Hall PA, Kearsey JM, Coates PJ, ''et al.'' |titolo=Characterisation of the interaction between PCNA and Gadd45. |rivista=Oncogene |volume=10 |numero= 12 |pagine= 2427–33 |anno= 1995 |pmidid=PMID 7784094 |doi= }}
* {{Cita pubblicazione | autore=Kato S, Sekine S, Oh SW, ''et al.'' |titolo=Construction of a human full-length cDNA bank. |rivista=Gene |volume=150 |numero= 2 |pagine= 243–50 |anno= 1995 |pmidid=PMID 7821789 |doi=10.1016/0378-1119(94)90433-2 }}
* {{Cita pubblicazione | autore=Matsuoka S, Yamaguchi M, Matsukage A |titolo=D-type cyclin-binding regions of proliferating cell nuclear antigen. |rivista=J. Biol. Chem. |volume=269 |numero= 15 |pagine= 11030–6 |anno= 1994 |pmidid=PMID 7908906 |doi= }}
* {{Cita pubblicazione | autore=Szepesi A, Gelfand EW, Lucas JJ |titolo=Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes. |rivista=Blood |volume=84 |numero= 10 |pagine= 3413–21 |anno= 1994 |pmidid=PMID 7949095 |doi= }}
* {{Cita pubblicazione | autore=Smith ML, Chen IT, Zhan Q, ''et al.'' |titolo=Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. |rivista=Science |volume=266 |numero= 5189 |pagine= 1376–80 |anno= 1994 |pmidid=PMID 7973727 |doi=10.1126/science.7973727 }}
* {{Cita pubblicazione | autore=Pan ZQ, Chen M, Hurwitz J |titolo=The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis. |rivista=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |numero= 1 |pagine= 6–10 |anno= 1993 |pmidid=PMID 8093561 |doi=10.1073/pnas.90.1.6 |pmc=45588}}
==Collegamenti esterni==
* {{Cita web| url = http://www-als.lbl.gov/als/science/sci_archive/80slidingclamp.html | titolo = Structure of a Clamp–Loader Complex | accesso=15 aprile 2008 | autore = Dan Krotz | wkautore = | coautori = | data = | opera = | editore = Advanced Light Source News | pagine = | lingua = | urlarchivio = | dataarchivio = | quote = }}
* {{Cita web| url = http://www.pubmedcentral.gov/picrender.fcgi?artid=1236569&blobname=pnas_0506447102_06447Movie2.mov | titolo = Movie showing a model of clamp loading of PCNA onto DNA | accesso=15 aprile 2008 | autore = | wkautore = | coautori = | data = | formato = | opera = | editore = | pagine = | lingua = | urlarchivio = | dataarchivio = | quote = }}
* {{Cita pubblicazione | autore = Miyata T, Suzuki H, Oyama T, Mayanagi K, Ishino Y, Morikawa K | titolo = Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis | rivista = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | numero = 39 | pagine = 13795–800 | anno = 2005 | pmid id=PMID 16169902 | doi = 10.1073/pnas.0506447102 }}
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