Anisotropic Network Model: Difference between revisions

Revision as of 12:44, 2 December 2011

Revision as of 08:10, 14 August 2012

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== Comparing ANM and GNM ==

ANM and GNM are both based on an elastic network model. The GNM has proven itself to accurately describe the vibrational dynamics of proteins and their complexes in numerous studies. Whereas the GNM is limited to the evaluation of the [[mean-square displacementssquared displacement]]s and cross-correlations between fluctuations, the motion being projected to a mode space of N dimensions, the ANM approach permits us to evaluate directional preferences and thus provides 3-D descriptions of the 3N - 6 internal modes.

It has been observed that GNM fluctuation predictions agree better with experiments than those computed with ANM. The higher performance of GNM can been attributed to its underlying potential, which takes account of orientational deformations, in addition to distance changes.