Graphical models for protein structure: Difference between revisions

Revision as of 20:31, 23 November 2012

Revision as of 18:58, 26 November 2012

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[[Graphical model]]s have become powerful frameworks for [[protein structure prediction]], [[protein–protein interaction]] and [[Thermodynamic free energy|free energy]] calculations for protein structures. Using a graphical model to represent the protein structure allows the solution of many problems including secondary structure prediction, protein protein interactions, protein-drug interaction, and free energy calculations.

There are two main approaches to use graphical models in protein structure modeling. The first approach uses [[Discrete mathematics|discrete]]{{dn|date=November 2012}} variables for representing coordinates or [[dihedral angle]]s of the protein structure. The variables are originally all continuous values and, to transform them into discrete values, a discretization process is typically applied. The second approach uses [[continuous]]{{dn|date=October 2012}} variables for the coordinates or dihedral angles.

==Discrete graphical models for protein structure==