Role of cell adhesions in neural development: Difference between revisions

Revision as of 23:44, 28 November 2012

Revision as of 23:52, 28 November 2012

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==Adhesion classifications==

* '''Cell-cell adhesions''' provide chemical and mechanical connections between adjacent cells. Of special importance to neuronal tissue development are the subcategory [[CDH2|n-cadherins]]. These cadherin molecules have been shown to be important in formation of the CNS structure, as well as neuronal migration along glial fibers.<ref>{{cite journal|last=Murase|first=S|title=The role of cell adhesion molecules in synaptic plasticity and memory.|journal=Current Opinion in Cell Biology|year=1999|month=Oct|volume=11|issue=5|pages=549-53}}</ref>

* '''Cell-'''[[Extracellular matrix|'''Extra-Cellular Matrix''']] (ECM) '''adhesions''' also form mechanical and chemical linkages, but the connection occurs between cellular-matrix and the extra-cellular matrix through a plethora of adhesive proteins that form cohesive functional units. These focal adhesion plaques are highly dynamic in nature and undergo a maturation process through which they have altered functionality and protein content. Maturation stages are summarized in the following table:

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