Acido ganoderico: differenze tra le versioni

Versione delle 13:36, 5 nov 2012

Versione delle 19:48, 8 nov 2012

Riga 1:

{{chembox

| verifiedrevid = 377859295

|Name=Ganoderic acid A

|ImageFile=Ganoderic acid.png

|ImageSize=200px

|IUPACName= (2''R'',6''R'')-6-[(5''R'',7''S'',10''S'',13''R'',14''R'',15''S'',17''R'')<br>-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,<br>11-dioxo-2,5,6,7,12,15,16,17<br>-octahydro-1H-cyclopenta[a]phenanthren-17-yl]<br>-2-methyl-4-oxoheptanoic acid

|OtherNames=

|Section1= {{Chembox Identifiers

| CASNo=81907-62-2

| PubChem=471002

| ChemSpiderID = 413668

| SMILES = OC(=O)[C@H](C)CC(=O)C[C@@H](C)[C@H]2C[C@H](O)[C@@]1(C)C/3=C(\C(=O)C[C@@]12C)[C@@]4(C)CCC(=O)[C@](C)(C)[C@@H]4C[C@@H]\3O

| InChI = 1/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1

| InChIKey = DYOKDAQBNHPJFD-JNTBEZBXBK

| StdInChI = 1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1

| StdInChIKey = DYOKDAQBNHPJFD-JNTBEZBXSA-N

}}

|Section2= {{Chembox Properties

| Formula=C₃₀H₄₄O₇

| MolarMass=516.67

| Appearance=

| Density=

| MeltingPt=

| BoilingPt=

| Solubility=

}}

|Section3= {{Chembox Hazards

| MainHazards=

| FlashPt=

| Autoignition=

}}

}}

'''Ganoderic acids''' are a class of closely related [[triterpenoid]]s ([[Derivative (chemistry)|derivatives]] from [[lanosterol]]) found in ''[[Ganoderma]]'' mushrooms. For thousands of years, the fruiting bodies of ''Ganoderma'' fungi have been used in traditional medicines in East Asia.<ref>T. Mizuno, G. Wang, J. Zhang, H. Kawagishi, T. Nishitoba, J. Li. ''Ganoderma lucidum'' and ''Ganoderma tsugae'': Bioactive substances and medicinal effects. ''Food Rev. Intern.'' (1995) '''11''': 151-166.</ref> Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including [[hepatoprotection]],{{Fact|date=January 2008}} anti-tumor effects,<ref>G. Wang, J. Zhao, J. Liu, Y. Huang, J.J. Zhong, W. Tang. Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. ''International Immunopharmacology '' (2007) '''7''': 864-870.</ref> and [[5-alpha reductase]] [[enzyme inhibitor|inhibition]].<ref>J. Liu, K. Kurashiki, K. Shimizu, R. Kondo. Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from ''Ganoderma lucidum''. '' Bioorganic & Medicinal Chemistry '' (2006) '''14''': 8654-8660. </ref>

==References==

<references/>

{{ketone-stub}}

[[Category:Triterpenes]]

[[Category:Alcohols]]

[[Category:Ketones]]

[[Category:Carboxylic acids]]

[[fa:گانودریک اسید]]