Tunable resistive pulse sensing: Difference between revisions

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Created page with ''''Tunable Resistive Pulse Sensing''' (TRPS) is a technique that allows high-throughput single particle measurements as colloids and/or biomolecular analytes are...'
 
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Nanopore-based detection allows particle-by-particle assessment of complex mixtures. Optimization of pore size to particle size, by adjusting the stretch of the pore, can improve measurement accuracy.
 
Through combination with fine-control of pressure TRPS has been used to determine sample concentration <ref>Willmott, G. R., Yu, S.S.C. and Vogel, R., “Pressure Dependence of Particle Transport Through Resizable Nanopores” &nbsp;Proceedings of ICONN, 128-131 (2010).</ref><ref>G. Seth Roberts, Sam Yu, Qinglu Zeng, Leslie C.L. Chan, Will Anderson, Aaron H. Colby, Mark W. Grinstaff, Steven Reid, Robert Vogel. “Tunable Pores for Measuring Concentrations of Synthetic and Biological Nanoparticle Dispersions” &nbsp;Biosensors and Bioelectronics, 31 pp. 17-25,  &nbsp;(2012).</ref> and to accurately derive particle electrophoretic mobility & surface charge<ref>"A variable pressure method for characterising nanoparticle surface charge using pore sensors" &nbsp;Robert Vogel, Will Anderson, James Eldridge, Ben Glossop, and Geoff Willmott. Anal. Chem., Just Accepted Manuscript DOI: 10.1021/ac2030915 Publication Date (Web): February 27 (2012).</ref> in addition to particle size information.
 
== Applications ==