Protective index: Difference between revisions

Revision as of 06:18, 5 July 2013

Revision as of 06:25, 5 July 2013

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defined level of toxicity in the presence of a nontoxic

dose of another chemical^{^{Bhat et al, 2007}}.

''Protective index = LD50 of A with B/LD50 of A alone''

''''Protective index = LD50 of A with B/LD50 of A alone''''

The higher the protective index , better is the

antidotal value of a given substance. Sometimes the

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a protective index of 3.2. The LD50 of potassium

cyanide in the presence of both nitrite and thiosulfate

is 52 mg/kg with a protective index of 4.73 (Way.

et al. 1972). Since the protective index is higher for

the simultaneous use of nitrite and thiosulfate, the

two chemicals constitute the antidote against cyanide