Human Protein Reference Database: Difference between revisions

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The '''Human Protein Reference Database''' (HPRD) is a protein database accessible through the internet.<ref>{{Cite journal |author=Peri S, ''et al.'' |title=Development of human protein reference database as an initial platform for approaching systems biology in humans |journal=Genome Research |year=2003 |volume=13 |pages=2363–71}}</ref>

==Overview==

The HPRD is a result of an international collaborative effort between the [http://www.ibioinformatics.org/ Institute of Bioinformatics] in Bangalore, India and the [http://pandeylab.igm.jhmi.edu/ Pandey lab] at [[Johns Hopkins University]] in Baltimore, USA. HPRD contains manually curated scientific information pertaining to the biology of most human proteins. Information regarding proteins involved in human diseases is annotated and linked to [http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim Online Mendelian InhertanceInheritance in Man] (OMIM) database. The [http://www.ncbi.nlm.nih.gov/ National Center for Biotechnology Information] provides link to HPRD through its human protein databases (e.g. [http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene Entrez Gene], [http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq protein]) pertaining to genes and proteins.

This resource depicts information on human protein functions including [[protein–protein interactions]], [[post-translational modifications]], enzyme-substrate relationships and disease associations. Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. The protein–protein interaction and subcellular localization data from HPRD have been used to develop a human protein interaction network.<ref>Gandhi, T.K.B. ''et al.'' Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. ''Nature Genetics''. 2006. 3, 285–293</ref>