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An '''Azadithiolateazadithiolate cofactor''' is an [[anion]] with the formula NH(CH<sub>2</sub>S)<sub>2</sub><sup>2-</sup>. It is used as a cofactor in the [FeFe] hydrogenases, [[enzymes|bacterial enzymes]] responsible for the reversible reduction of 2 H<sup>+</sup> to H<sub>2</sub>.<ref>Berggren, G., Adamska, A., Lambertz, C., Simmons, T. R., Esselborn, J., Atta, A., Gambarelli, S., Mouesca, J.-M., Reijerse, E., Lubitz, W., Happe, T., Artero, V., Fontecave, M. "Biomimetic assembly and activiation of [FeFe]-hydrogenases" ''Nature'' 2013, vol. 499, 66 {{DOI|10.1038/nature12239}}</ref> As a cofactor, the two thiolate functional groups are bound to each of the two irons in the active site of the enzyme. The amine functional group serves as an acid/base to transfer H<sup>+</sup> from the solution to the active site.
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