Signal transducing adaptor molecule: Difference between revisions

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Revision as of 01:44, 30 January 2014

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{{PBB|geneid=8027}}

'''Signal transducing adapter molecule 1''' is a [[protein]] that in humans is encoded by the ''STAM'' [[gene]].<ref name="pmid8780729">{{cite journal | author = Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K | title = Cloning of a novel signal-transducing adaptor molecule containing an SH3 ___domain and ITAM | journal = Biochem Biophys Res Commun | volume = 225 | issue = 3 | pages = 1035–9 | year date=October 1996 | month = October | pmid = 8780729 | pmc = | doi = 10.1006/bbrc.1996.1290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

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==Interactions==

Signal transducing adaptor molecule has been shown to [[Protein-protein interaction|interact]] with [[STAMBP]],<ref name=pmid10982817>{{cite journal |last=Kato |first=M |authorlink= |coauthors=Miyazawa K, Kitamura N |yeardate=December 2000|month=December |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP |journal=J. Biol. Chem. |volume=275 |issue=48 |pages=37481–7 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10982817 |doi = 10.1074/jbc.M007251200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10383417>{{cite journal |last=Tanaka |first=N |authorlink= |coauthors=Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K |yeardate=July 1999|month=July |title=Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines |journal=J. Biol. Chem. |volume=274 |issue=27 |pages=19129–35 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10383417 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.27.19129 }}</ref> [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |yeardate=October 2005|month=October |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |___location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9407053>{{cite journal |last=Asao |first=H |authorlink= |coauthors=Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K |yeardate=December 1997|month=December |title=Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth |journal=J. Biol. Chem. |volume=272 |issue=52 |pages=32785–91 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 9407053 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.52.32785 }}</ref><ref name=pmid12551915>{{cite journal |last=Bache |first=Kristi G |authorlink= |coauthors=Raiborg Camilla, Mehlum Anja, Stenmark Harald |yeardate=April 2003|month=April |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes |journal=J. Biol. Chem. |volume=278 |issue=14 |pages=12513–21 |publisher= |___location = United States| issn = 0021-9258| pmid = 12551915 |doi = 10.1074/jbc.M210843200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TIMM8A]]<ref name=pmid12745081>{{cite journal |last=Blackstone |first=Craig |authorlink= |coauthors=Roberts Roland G, Seeburg Daniel P, Sheng Morgan |yeardate=May 2003|month=May |title=Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue=2 |pages=345–52 |publisher= |___location = United States| issn = 0006-291X| pmid = 12745081 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)00767-8 }}</ref> and [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal |last=Takeshita |first=T |authorlink= |coauthors=Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K |yeardate=April 1997|month=April |title=STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction |journal=Immunity |volume=6 |issue=4 |pages=449–57 |publisher= |___location = UNITED STATES| issn = 1074-7613| pmid = 9133424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1074-7613(00)80288-5 }}</ref>

==References==