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The '''Toxin and Toxin-Target Database (T3DB)'''<ref name=pmid19897546></ref> is a comprehensive, high-quality, freely accessible, online database of common toxic substances and their protein/DNA or organ targets. The database currently houses 3,053 toxic compounds or poisons described by 32,276 synonyms. This list includes common pollutants, pesticides, drugs, and food toxins. These toxic substances are linked to 1,670 corresponding protein/DNA target records. In total there are 37,084 toxic substance-toxin target associations. Each toxic compound record (ToxCard) in T3DB contains nearly 60 data fields and holds information such as chemical properties and descriptors, mechanisms of action, toxicity or lethal-dose values, molecular and cellular interactions, and medical (symptom and treatment) information. This information has been extracted from over 5,454 sources[http://classic.t3db.org/sources sources], which include other databases, government documents, books, and scientific literature.
The primary focus of the T3DB is on providing mechanisms of toxicity and identifying target proteins for common toxic substances. While a number of other toxic compound databases do exist, their emphasis is on covering large numbers of chemical compounds that are almost never seen outside a chemical laboratory. T3DB attempts to capture data on only those toxic substances that are abundant or in widespread use and have been detected or measured in humans. T3DB is fully searchable and supports extensive text, sequence, chemical structure, and relational query searches. It is both modelled after and closely linked to the [[Human Metabolome Database]] ([[HMDB]]) and [[DrugBank]]. Potential applications of T3DB include metabolomics and environmental exposure studies, toxic compound metabolism prediction, toxin/drug interaction prediction, and general toxic substance awareness.
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