The progenitors,or the(those cells that will become, CNCCs), are found in the [[epiblast]] around [[Primitive knot|Henson’s node]].<ref name="kur" /><ref name = "kirby2010">{{cite journal|last=Kirby|first=M.K.|coauthors=Hutson, M.R.|title=Factors controlling cardiac neural crest cell migration|journal=Cell Adhesion and Migration|date=December 2010|volume=4|issue=4|pages=609–621|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011257/pdf/cam0404_0609.pdf|pmc=3011257|pmid=20890117}}</ref> The progenitorsprogenitor cells are brought into the [[neural foldsfold]]s and signalingmolecules fromsuch moleculesas Wnt, FGF and BMP helpprovide induce[[signaling|signals]] thewhich induce progenitorsthem to become CNCCs.<ref name="kur" /><ref name="kirby2010" /> Not a lotLittle is known about the signaling cascades (activities) that occur forallow neural crest induction,butto occur. However, it is known that an intermediate level of BMP is needed,required: if BMP is too high or too low causes, the cells notdo tonot migrate.<ref name="kirby2010" />
