Toxin and Toxin-Target Database: Difference between revisions

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The '''Toxin and Toxin-Target Database (T3DB)'''<ref name=pmid19897546></ref> is a comprehensive, high-quality, freely accessible, online database of common [[toxic substancessubstance]]s and their [[protein]]/[[DNA]] or organ targets. The database currently houses 3,053 toxic compounds or [[poisons]] described by 32,276 synonyms. This list includes common [[pollutants]], [[pesticides]], [[drugs]], and food [[toxins]]. These toxic substances are linked to 1,670 corresponding protein/DNA target records. In total there are 37,084 toxic substance-toxin target associations. Each toxic compound record (ToxCard) in T3DB contains nearly 60 data fields and holds information such as chemical properties and descriptors, [[mechanisms of action]], [[toxicity]] or [[lethal- dose]] values, molecular and cellular interactions, and medical (symptom and treatment) information. This information has been extracted from over 5,454 [http://classic.t3db.org/sources sources], which include [http://classic.t3db.org/databases other databases], government documents, books, and scientific literature.

The primary focus of the T3DB is on providing mechanisms of [[toxicity]] and identifying target [[proteins]] for common [[toxic substances]]. While a number of other toxic compound databases do exist, their emphasis is on covering large numbers of chemical compounds that are almost never seen outside a chemical laboratory. T3DB attempts to capture data on only those [[toxic substances]] that are abundant or in widespread use and have been detected or measured in humans. T3DB is fully searchable and supports extensive text, sequence, [[chemical structure]], and [[relational query]] searches. It is both modelled after and closely linked to the [[Human Metabolome Database]] ([[HMDB]]) and [[DrugBank]]. Potential applications of T3DB include [[metabolomics]] and environmental exposure studies, toxic compound [[metabolism]] prediction, toxin/drug interaction prediction, and general toxic substance awareness.

==Scope and Access==