Cardiac neural crest: Difference between revisions

Revision as of 19:39, 26 February 2014

Revision as of 07:43, 2 March 2014

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=== Induction ===

''Induction'' is the differentiation of progenitor cells into their final designation or type. The progenitor cells which will become CNCCs are found in the [[epiblast]] about [[Primitive knot|Henson’s node]].<ref name="Kuratani (1992)"/><ref name="Kirby (2010)">Kirby M. K. and Hutson M. R. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011257/pdf/cam0404_0609.pdf "Factors controlling cardiac neural crest cell migration."] Cell Adhesion and Migration, December 2010, 4(4) p609 - 621 pmc3011257 pmid20890117.</ref> Progenitor cells are brought into the [[neural fold]]s. Molecules such as [[Wnt signaling pathway|Wnt]], [[fibroblast growth factor]] (FGF) and [[bone morphogenetic protein]] (BMP) provide [[signalingRecognition signal|signalssignal]]s which induce the progenitor cells to become CNCCs.<ref name="Kuratani (1992)"/><ref name="Kirby (2010)"/> Little is known about the signal cascade that promotes neural crest induction. However, it is known that an intermediate level of BMP is required: if BMP is too high or too low, the cells do not migrate.<ref name="Kirby (2010)"/>

=== Initial migration ===