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As with any physical theory, there are limits to the validity of the virtual particle picture. The virtual-particle formulation is derived from a method known as [[perturbation theory]] which is an approximation assuming interactions are not too strong, and was intended for scattering problems, not bound states such as atoms. For the strong force binding [[quark]]s into [[nucleon]]s at low energies, perturbation theory has never been shown to yield results in accord with experiments,<ref>[http://www.hep.phy.cam.ac.uk/theory/research/hadronic.html]</ref> thus, the validity of the "force-mediating particle" picture is questionable. Similarly, for [[bound state]]s the method fails.<ref>[http://galileo.phys.virginia.edu/classes/752.mf1i.spring03/Time_Ind_PT.htm]</ref> In these cases the physical interpretation must be re-examined.
As an example, the calculations of atomic structure in atomic physics or of molecular structure in quantum chemistry could not easily be repeated, if at all, using the "force-mediating particle" picture.{{fact}}
Additionally, one should look critically at the recent CERN experiments in which evidence is shown supporting the physical reality of the Higgs boson, which is a force-mediating particle. One should be careful not to make the logical error known as [[Reification (fallacy)|reification]], which confuses concept and reality.
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