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'''Critical process parameters''' (CPP) in pharmaceutical manufacturing are key variables affecting the production process. CPPs are attributes that are monitored to detect deviations in standardized production operations and product output quality or changes in [[Critical Quality Attributes]]. Those attributes with a higher impact on CQAs should be prioritized and held in a stricter state of control. The manufacturer should conduct test to set acceptable range limits of the determined CPPs and define acceptable process variable variability.<ref>{{cite web|title=Determining Criticality-Process Parameters and Quality Attributes Part I: Criticality as a Continuum|url=http://www.biopharminternational.com/biopharm/article/articleDetail.jsp?id=830461&pageID=1|publisher=biopharminternational|accessdate=10 November 2014}}</ref>
One method of defining CPPs is to look at the effect of certain production processes on critical quality attributes. Those production parameters which have a measurable effect on those quality attributes that have been identified as critical can be considered CPPs and must always be in a state of control. <ref>{{cite web|title=Critical Process Parameters (CPP)|url=http://www.atris-systems.com/cms/index.php?id=217|publisher=Atris Information Systems|accessdate=10 November 2014}}</ref>▼
▲One method of defining CPPs is to look at the effect of certain production processes on critical quality attributes. Those production parameters which have a measurable effect on those quality attributes that have been identified as critical can be considered CPPs and must always be in a state of control.
==References==
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