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2,4-D was one of the main ingredients of [[Agent Orange]], the defoliant used during the [[Vietnam War]] that was blamed for many health problems. The health problems arose from [[2,3,7,8-Tetrachlorodibenzodioxin|dioxin]] contamination created in the synthesis of the other Agent Orange component, [[2,4,5-T]], not from 2,4,-D, but the association nonetheless caused alarm.<ref name=gillam/>
General criticism is aimed at the concept of using herbicides with herbicide-resistant crops as it is likely that herbicide-resistant weeds will develop naturally in response. Thus agriculture moves from substance to substance in an ongoing "chemical arms race".<ref name=freese >{{cite web| url=http://www.centerforfoodsafety.org/files/fsr_24-d.pdf| author=[[Bill Freese]] |title=Going Backwards: Dow’s 2,4-D-Resistant Crops and a More Toxic Future| publisher=[[Center for Food Safety]]| title=”Agent Orange” Crops: The Next Stage in the Chemical Arms Race| accessdate=May 3, 2014}}</ref><ref name=gillam>{{cite web| url=http://www.cornucopia.org/2013/01/dows-controversial-new-gmo-corn-delayed-amid-protests/| author= Carey Gillam| title=Dow’s Controversial New GMO Corn Delayed Amid Protests|publisher=The Cornucopia Institute| date=January 28, 2013 |accessdate=May 3, 2014}}</ref> Critics point out that the process never ends and is not sustainable.<ref name=freese/> Instead, they reject herbicides and pesticides in favor of the use of non-toxic, sustainable methods to control pests and enrich the soil.<ref name=freese/>
However, weeds develop resistance whenever there is an over reliance on any given tool for weed control. Therefore, no single tool will ever be sustainable, non-toxic or otherwise. Sustainable solutions require integration of multiple technical approaches used in rotation over time.
==External links==
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