Nested case–control study: Difference between revisions

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A '''nested case control (NCC) study''' is a variation of a [[case-control study]] in which only a subset of controls from the cohort are compared to the incident cases. In a case-controlcohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest. In contrast, in a nested-case-control study, some number of controls are selected for each case from that case's matched risk set. By matching on factors such as age and selecting controls from relevant risk sets, the nested case control model is generally more efficient than a case-cohort design with the same number of selected controls.

Usually, the exposure of interest is only measured among the cases and the selected controls. Thus the nested case control study is less efficient than the full cohort design. The nested case control study can be analyzed using methods for missing covariates.<ref name=Cai/>