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The '''reliability theory of aging''' is an attempt to apply the principles of [[reliability theory]] to [[human biology]]. The theory was published in Russian by [[Leonid A. Gavrilov]] and Natalia S. Gavrilova as ''Biologiia prodolzhitelʹnosti zhizni'' in 1986, and in English translation as ''The Biology of Life Span: A Quantitative Approach'' in 1991.{{r|gav|rayl}}
The [[hypothesis]] is based on the unusual [[premise]] that humans are born in a highly defective state. According to the [[mathematical model|model]], this is then made worse by environmental and mutational damage; [[redundancy]] allows the organism to survive for a while.{{r|ieee}}
==References==
{{reflist|refs=
<ref name=ieee>[s.n.] (1 September 2004). [https://web.archive.org/web/20140423124046/http://spectrum.ieee.org/biomedical/devices/engineering-and-aging-the-best-is-yet-to-be Engineering and Aging: The Best Is Yet to Be]. IEEE Spectrum. Archived 23 April 2014.</ref>
<ref name=rayl>A.J.S. Rayl (May 2002). <!--- please do not link to healthsters.com - copyright violation--->Aging, in Theory: A Personal Pursuit. Do body system redundancies hold the key? ''The Scientist'' '''16''' (10): 20.</ref>
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==Further reading==
* Gavrilov LA, Gavrilova NS. [http://www.elsevierdirect.com/product.jsp?isbn=9780120883875 Reliability Theory of Aging and Longevity.] In: Masoro E.J. & Austad S.N.. (eds.): Handbook of the Biology of Aging, Sixth Edition. Academic Press. San Diego, CA, USA, 2006, 3-42. ISBN 0-12-088387-2
* Gavrilov LA, Gavrilova NS. [http://longevity-science.org/Failure-Models-2006.pdf Models of Systems Failure in Aging. ] In: P Michael Conn (Editor): Handbook of Models for Human Aging, Burlington, MA : Elsevier Academic Press, 2006. 45-68. ISBN 0-12-369391-8.
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* Gavrilov L.A., Gavrilova N.S. [http://longevity-science.org/JTB-01.pdf The reliability theory of aging and longevity]. Journal of Theoretical Biology, 2001, 213(4): 527-545. {{DOI|10.1006/jtbi.2001.2430}} PMID 11742523
* Abernethy, John. Gompertzian mortality originates in the winding-down of the mitotic clock. Journal of Theoretical Biology, 1998, 192, 419-435.
▲* [[Leonid A. Gavrilov]] & [[Natalia S. Gavrilova]] (1991), ''The Biology of Life Span: A Quantitative Approach''. New York: Harwood Academic Publisher, ISBN 3-7186-4983-7
* Gavrilov, L.A. A mathematical model of the aging of animals. Proc. Acad. Sci. USSR [Doklady Akademii Nauk SSSR], 1978, 238(2): 490-492. English translation by Plenum Publ Corp: pp.53-55. PMID 624242
* Abernethy JD. The exponential increase in mortality rate with age attributed to wearing-out of biological components. Journal of Theoretical Biology, 1979, 80, 333-354.
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* Witten, T.M., Information content of biological survival curves arising in aging experiments: Some further thoughts, (in) Evolution of Aging Processes in Animals (ed.) A. Woodhead and K.H. Thompson (Plenum Press, N.Y., 1987).
* Witten, T.M., A return to time, cells, systems, and aging: V. Further thoughts on Gompertzian survival dynamics --- the geriatric years, Mech. Aging and Dev., 46(1988) 175-200.
==External links==
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