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2,4-D was one of the main ingredients of [[Agent Orange]], a defoliant used during the [[Vietnam War]] that was blamed for many health problems. The health problems arose from [[2,3,7,8-Tetrachlorodibenzodioxin|dioxin]] contamination created in the synthesis of the other Agent Orange component, [[2,4,5-T]], not from 2,4,-D, but the association nonetheless caused alarm.<ref name=gillam>{{cite web| url=http://www.cornucopia.org/2013/01/dows-controversial-new-gmo-corn-delayed-amid-protests/| author= Carey Gillam| title=Dow’s Controversial New GMO Corn Delayed Amid Protests|publisher=The Cornucopia Institute| date=January 28, 2013 |accessdate=May 3, 2014}}</ref>
The [[U.S. Environmental Protection Agency]] has moved to rescind its approval of use {{mdash}} in part due to conflicting claims: (1) to the EPA about the unchanged harmlessness of the combination of the two defoliants' and (2) those in the [[Patent application]] asserting the enhanced "synergistic effect."<ref name="NPR">{{cite news |first1=Dan |last1=Charles |publisher=[[National Public Radio]] |title=Busted: EPA discovers DOW
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