Microprocessor complex subunit DGCR8: Difference between revisions

Revision as of 23:41, 12 February 2016

Revision as of 00:16, 17 February 2016

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{{PBB|geneid=54487}}

The '''DGCR8''' microprocessor complex subunit ''([[DiGeorge syndrome]] chromosomal'' [or ''critical''] ''region 8)'' is a [[protein]] that in humans is encoded by the ''DGCR8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54487| accessdate = }}</ref> In other animals, particularly the common [[model organism]]s ''[[Drosophila melanogaster]]'' and ''[[Caenorhabditis elegans]]'', the protein is known as ''Pasha'' (partner of [[Drosha]]).<ref>{{cite journal | vauthors = Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ | title = Processing of primary microRNAs by the Microprocessor complex | journal = Nature | volume = 432 | issue = 7014 | pages = 231–5 | date = Nov 2004 | pmid = 15531879 | doi = 10.1038/nature03049 }}</ref> It is a required component of the [[RNA interference]] pathway.

== Function ==