Community Programs for Clinical Research on AIDS: Difference between revisions

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{{primary sources|date=July 2007}}

{{Underlinked|date=November 2015}}

The '''Community Programs for Clinical Research on AIDS''' ('''CPCRA''') was a programme sponsored by [[National Institutes of Health]] (NIH) in the United States.<ref>[http://link.springer.com/article/10.1007%2FBF01964462]</ref><ref>{{cite newsjournal |url=http://cpcra.s-3.com/docs/pubs/papers/Method-Cox.pdf |journal=Health Soc Work |date= November 1998 |volume=23 |issue=4 |pages=290-7 |title=Community advisory boards: their role in AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS |last1=Cox |first1=LE |last2=Rouff |first2=JR |last3=Svendsen |first3=KH |last4=Markowitz |first4=M |last5=Abrams |first5=DI}}</ref>

==History==

The CPCRA was established in 1989<ref>{{cite web |url=https://aspe.hhs.gov/report/inventory-federally-sponsored-hiv-and-hiv-relevant-databases/database-terry-beirn-community-programs-clinical-research-aids-cpcra-observational-data-base-odb |title=An inventory of federally sponsored HIV and HIV-relevant databases. Database:Terry Beirn community programs for clinical research on AIDS (CPCRA) observational database (ODB) |publisher=[[Assistant Secretary for Planning and Evaluation]] (ASPE) |date=7 January 2000 |accessdate=21 April 2016}}</ref> and included 15 research units. A Statistical Center at the [[University of Minnesota]] was funded from 1990 to 1997.<ref>[http://grantome.com/grant/NIH/N01-AI005073-017 research grant information]</ref><ref>[http://www.rdatlas.com/portal/portal.cfm?page=grants&applicationid=2296440]</ref>

The CPCRA was one of four networks that NIH was using to conduct clinical trials that were looking to understand possible therapies for people with HIV infection.<ref>{{cite press release |url=https://aidsinfo.nih.gov/news/123/niaid-research-on-aids |title=NIAID Research on AIDS |publisher=aidsinfo.nih.gov |date= 1 January 1995 |accessdate=22 SeptemberApril 2016}}</ref> Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."<ref>[http://cpcra.s-3.com/]</ref>

The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and [[unintended consequence]]s of various treatment strategies using available agents to assess long-term immunologic, virologic and clinical outcomes. CPCRA trials are designed with nested substudies aimed at understanding the pathogenesis of HIV infection and the public health implications of its treatment.<ref>[http://www.niaid.nih.gov/DAIDs/pdatguide/cpcra.htm]{{dead link|date=April 2016}}</ref>