API5: Difference between revisions

Revision as of 10:25, 23 March 2016

Revision as of 18:00, 15 May 2016

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{{PBB|geneid=8539}}

The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | author vauthors= Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Res | volume = 57 | issue = 18 | pages = 4063–9 |date=Oct 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>

This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs.

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{{PBB_Further_reading

| citations =

*{{cite journal | authorvauthors=Gianfrancesco F, Esposito T, Ciccodicola A |title=Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 164–6 |year= 1999 |pmid= 10393420 |doi=10.1159/000015247 |display-authors=etal}}

*{{cite journal | authorvauthors=Kim JW, Cho HS, Kim JH |title=AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. |journal=Lab. Invest. |volume=80 |issue= 4 |pages= 587–94 |year= 2000 |pmid= 10780674 |doi=10.1038/labinvest.3780008 |display-authors=etal}}

*{{cite journal | authorvauthors=Van den Berghe L, Laurell H, Huez I |title=FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1709–24 |year= 2001 |pmid= 11075807 |doi=10.1210/me.14.11.1709 |display-authors=etal}}

*{{cite journal | authorvauthors=Sutherland HG, Mumford GK, Newton K |title=Large-scale identification of mammalian proteins localized to nuclear sub-compartments. |journal=Hum. Mol. Genet. |volume=10 |issue= 18 |pages= 1995–2011 |year= 2001 |pmid= 11555636 |doi=10.1093/hmg/10.18.1995 |display-authors=etal}}

*{{cite journal | authorvauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}

*{{cite journal | authorvauthors=Li Z, Hu CY, Mo BQ |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380–4 |year= 2003 |pmid= 12703993 |doi= |display-authors=etal}}

*{{cite journal | authorvauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

*{{cite journal | authorvauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}

*{{cite journal | authorvauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}

*{{cite journal | authorvauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}

*{{cite journal | authorvauthors=Morris EJ, Michaud WA, Ji JY |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 | pmc=1636698 |display-authors=etal}} {{open access}}

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