|
== Therapeutic applications ==
The drug [[eculizumab]] (trade name '''Soliris''') prevents cleavage of C5 into C5a and C5b.<ref>{{cite journal | title=Eculizumab| authorvauthors=Dubois E, Cohen A| journal=Br J Clin Pharmacol| year=2009| volume=68| pages=318–319| pmc=2766470 |doi=10.1111/j.1365-2125.2009.03491.x | issue=3 | pmid=19740388}}</ref>
== Complement system pathway ==
==Further reading==
{{refbegin | 2}}
*{{cite journal | authorvauthors=Tack BF, Morris SC, Prahl JW |title=Fifth component of human complement: purification from plasma and polypeptide chain structure |journal=Biochemistry |volume=18 |issue= 8 |pages= 1490–7 |year= 1979 |pmid= 106884 |doi=10.1021/bi00575a016 }}
*{{cite journal | authorvauthors=Fernandez HN, Hugli TE |title=Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a |journal=J. Biol. Chem. |volume=253 |issue= 19 |pages= 6955–64 |year= 1978 |pmid= 690134 |doi= }}
*{{cite journal | author=DiScipio RG |title=Formation and structure of the C5b-7 complex of the lytic pathway of complement |journal=J. Biol. Chem. |volume=267 |issue= 24 |pages= 17087–94 |year= 1992 |pmid= 1387399 |doi= }}
*{{cite journal | authorvauthors=Haviland DL, Haviland JC, Fleischer DT |title=Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene |journal=J. Immunol. |volume=146 |issue= 1 |pages= 362–8 |year= 1991 |pmid= 1984448 |doi= |display-authors=etal}}
*{{cite journal | authorvauthors=Bohnsack JF, Mollison KW, Buko AM |title=Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus |journal=Biochem. J. |volume=273 |issue= Pt 3|pages= 635–40 |year= 1991 |pmid= 1996961 |doi= | pmc=1149811 |display-authors=etal}}
*{{cite journal | authorvauthors=Lundwall AB, Wetsel RA, Kristensen T |title=Isolation and sequence analysis of a cDNA clone encoding the fifth complement component |journal=J. Biol. Chem. |volume=260 |issue= 4 |pages= 2108–12 |year= 1985 |pmid= 2579066 |doi= |display-authors=etal}}
*{{cite journal | authorvauthors=Zuiderweg ER, Fesik SW |title=Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a |journal=Biochemistry |volume=28 |issue= 6 |pages= 2387–91 |year= 1989 |pmid= 2730871 |doi=10.1021/bi00432a008 }}
*{{cite journal | authorvauthors=Zuiderweg ER, Nettesheim DG, Mollison KW, Carter GW |title=Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data |journal=Biochemistry |volume=28 |issue= 1 |pages= 172–85 |year= 1989 |pmid= 2784981 |doi=10.1021/bi00427a025 }}
*{{cite journal | authorvauthors=Haefliger JA, Tschopp J, Vial N, Jenne DE |title=Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding ___domain in complement C6 |journal=J. Biol. Chem. |volume=264 |issue= 30 |pages= 18041–51 |year= 1989 |pmid= 2808363 |doi= }}
*{{cite journal | authorvauthors=Wetsel RA, Lemons RS, Le Beau MM |title=Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9 |journal=Biochemistry |volume=27 |issue= 5 |pages= 1474–82 |year= 1988 |pmid= 3365401 |doi=10.1021/bi00405a012 |display-authors=etal}}
*{{cite journal | authorvauthors=Zuiderweg ER, Mollison KW, Henkin J, Carter GW |title=Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a |journal=Biochemistry |volume=27 |issue= 10 |pages= 3568–80 |year= 1988 |pmid= 3408713 |doi=10.1021/bi00410a007 }}
*{{cite journal | authorvauthors=Stewart JL, Kolb WP, Sodetz JM |title=Evidence that C5b recognizes and mediates C8 incorporation into the cytolytic complex of complement |journal=J. Immunol. |volume=139 |issue= 6 |pages= 1960–4 |year= 1987 |pmid= 3624872 |doi= }}
*{{cite journal | authorvauthors=Buhl AM, Osawa S, Johnson GL |title=Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 19828–32 |year= 1995 |pmid= 7649993 |doi=10.1074/jbc.270.34.19828 }}
*{{cite journal | authorvauthors=Babkina IN, Seregin SV, Daniliuk NK |title=[Chemico-enzymatic synthesis, cloning and expression of a gene for an analog of human anaphylatoxin C5a] |journal=Bioorg. Khim. |volume=21 |issue= 5 |pages= 359–64 |year= 1995 |pmid= 7661861 |doi= |display-authors=etal}}
*{{cite journal | authorvauthors=Wang X, Fleischer DT, Whitehead WT |title=Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families |journal=J. Immunol. |volume=154 |issue= 10 |pages= 5464–71 |year= 1995 |pmid= 7730648 |doi= |display-authors=etal}}
*{{cite journal | authorvauthors=Oppermann M, Götze O |title=Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors |journal=Immunology |volume=82 |issue= 4 |pages= 516–21 |year= 1995 |pmid= 7835913 |doi= | pmc=1414921 }}
*{{cite journal | authorvauthors=Süsal C, Kirschfink M, Kröpelin M |title=Complement activation by recombinant HIV-1 glycoprotein gp120 |journal=J. Immunol. |volume=152 |issue= 12 |pages= 6028–34 |year= 1994 |pmid= 7911492 |doi= |display-authors=etal}}
*{{cite journal | authorvauthors=Arribas J, Arizti P, Castaño JG |title=Antibodies against the C2 COOH-terminal region discriminate the active and latent forms of the multicatalytic proteinase complex |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12858–64 |year= 1994 |pmid= 8175701 |doi= }}
*{{cite journal | authorvauthors=Süsal C, Kirschfink M, Kröpelin M |title=Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120 |journal=Blood |volume=87 |issue= 6 |pages= 2329–36 |year= 1996 |pmid= 8630395 |doi= |display-authors=etal}}
*{{cite journal | authorvauthors=Ames RS, Li Y, Sarau HM |title=Molecular cloning and characterization of the human anaphylatoxin C3a receptor |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20231–4 |year= 1996 |pmid= 8702752 |doi=10.1074/jbc.271.34.20231 |display-authors=etal}}
*{{cite journal | authorvauthors=Fredslund F, Laursen NS, Roversi P | title=Structure of and influence of a tick complement inhibitor on human complement component 5 | journal=Nat Immunol. |volume= 9 |issue= 7 |pages= 753–60 |year= 2008 |pmid= 18536718 | doi=10.1038/ni.1625 |display-authors=etal}}
{{refend}}
| 