Primitive neuroectodermal tumor: Difference between revisions

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Revision as of 00:35, 27 May 2016

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==Model==

Using gene transfer of SV40 large T-antigen in neuronal precursor cells of rats, a brain tumor model was established. The PNETs were histologically indistinguishable from the human counterparts and have been used to identify new genes involved in human brain tumor carcinogenesis.<ref name="pmid8129041">{{cite journal |authorvauthors=Eibl RH, Kleihues P, Jat PS, Wiestler OD |title=A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen |journal=Am. J. Pathol. |volume=144 |issue=3 |pages=556–64 |date=March 1994 |pmid=8129041 |pmc=1887088 |doi= |url=}}</ref> The model was used to confirm p53 as one of the genes involved in human medulloblastomas, but since only about 10% of the human tumors showed mutations in that gene, the model can be used to identify the other binding partners of SV40 Large T- antigen, other than p53.<ref name="pmid1933879">{{cite journal |authorvauthors=Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P |title=p53 mutations in nonastrocytic human brain tumors |journal=Cancer Res. |volume=51 |issue=22 |pages=6202–5 |date=November 1991 |pmid=1933879 |doi= |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=1933879}}</ref>

==See also==