Nkx2-2as: Difference between revisions

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Revision as of 14:06, 4 June 2016

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'''Nkx2-2as''' (Nkx2-2 antisense) is a [[long non-coding RNA]]. It is located in the [[cytoplasm]] of the [[cell (biology)|cell]]. Nkx2-2as is involved in [[Neural development]]. Overexpression of Nkx2-2as results in increased levels of expression of the [[homeobox]] gene [[NKX2-2 | Nkx2-2]] and enhances induction of the [[Cellular differentiation | differentiation]] of [[oligodendrocytes]].<ref name="pmid18538132">{{cite journal |authorvauthors=Tochitani S, Hayashizaki Y |title=Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation |journal=Biochem. Biophys. Res. Commun. |volume=372 |issue=4 |pages=691–6 |date=August 2008 |pmid=18538132 |doi=10.1016/j.bbrc.2008.05.127 |url=}}</ref><ref name=Szyma>{{Citation

| title = Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System

| url = http://www.springerlink.com/index/l4016j727530qm70.pdf

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| last3 = Ski | first3 = M.

| last4 = Barciszewski | first4 = J.

| accessdate = 2011-03-25 }}</ref><ref name="pmid20137068">{{cite journal |authorvauthors=Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF |title=Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. |journal=BMC Neurosci |volume=11 |issue= |pages=14 |year=2010 |pmid=20137068 |doi=10.1186/1471-2202-11-14 |pmc=2829031}}</ref><ref name="pmid20380817">{{cite journal |authorvauthors=Qureshi IA, Mattick JS, Mehler MF |title=Long non-coding RNAs in nervous system function and disease. |journal=Brain Res |volume=1338 |issue= |pages=20–35 |year=2010 |pmid=20380817 |doi=10.1016/j.brainres.2010.03.110 |pmc=2883659}}</ref> Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes. <ref name="pmid18538132" /><ref name=Szyma />

__NOTOC__

==See also==

* [[Long non-coding RNA]]

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* {{cite journal |author=Mattick JS |title=The genetic signatures of noncoding RNAs |journal=PLoS Genet. |volume=5 |issue=4 |pages=e1000459 |date=April 2009 |pmid=19390609 |pmc=2667263 |doi=10.1371/journal.pgen.1000459 |url=}}

==External links==

* [http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=201818 MGI entry for Nkx2-2as]