Signal transducing adaptor molecule: Difference between revisions

Revision as of 14:04, 20 May 2016

Revision as of 21:58, 5 June 2016

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{{Infobox_gene}}

'''Signal transducing adapter molecule 1''' is a [[protein]] that in humans is encoded by the ''STAM'' [[gene]].<ref name="pmid8780729">{{cite journal | author vauthors= Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K | title = Cloning of a novel signal-transducing adaptor molecule containing an SH3 ___domain and ITAM | journal = Biochem Biophys Res Commun | volume = 225 | issue = 3 | pages = 1035–9 |date=October 1996 | pmid = 8780729 | pmc = | doi = 10.1006/bbrc.1996.1290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM signal transducing adaptor molecule (SH3 ___domain and ITAM motif) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8027| accessdate = }}</ref>

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==Interactions==

Signal transducing adaptor molecule has been shown to [[Protein-protein interaction|interact]] with [[STAMBP]],<ref name=pmid10982817>{{cite journal |last=Kato |first=M |authorlink= |author2=Miyazawa K |author3=Kitamura N |date=December 2000 |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP |journal=J. Biol. Chem. |volume=275 |issue=48 |pages=37481–7 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10982817 |doi = 10.1074/jbc.M007251200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10383417>{{cite journal |last=Tanaka |first=N |authorlink= |author2=Kaneko K |author3=Asao H |author4=Kasai H |author5=Endo Y |author6=Fujita T |author7=Takeshita T |author8=Sugamura K |date=July 1999 |title=Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines |journal=J. Biol. Chem. |volume=274 |issue=27 |pages=19129–35 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 10383417 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.27.19129 }}</ref> [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |date=October 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |___location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9407053>{{cite journal |last=Asao |first=H |authorlink= |author2=Sasaki Y |author3=Arita T |author4=Tanaka N |author5=Endo K |author6=Kasai H |author7=Takeshita T |author8=Endo Y |author9=Fujita T |author10=Sugamura K |date=December 1997 |title=Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth |journal=J. Biol. Chem. |volume=272 |issue=52 |pages=32785–91 |publisher= |___location = UNITED STATES| issn = 0021-9258| pmid = 9407053 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.52.32785 }}</ref><ref name=pmid12551915>{{cite journal |last=Bache |first=Kristi G |authorlink= |author2=Raiborg Camilla |author3=Mehlum Anja |author4=Stenmark Harald |date=April 2003 |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes |journal=J. Biol. Chem. |volume=278 |issue=14 |pages=12513–21 |publisher= |___location = United States| issn = 0021-9258| pmid = 12551915 |doi = 10.1074/jbc.M210843200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TIMM8A]]<ref name=pmid12745081>{{cite journal |last=Blackstone |first=Craig |authorlink= |author2=Roberts Roland G |author3=Seeburg Daniel P |author4=Sheng Morgan |date=May 2003 |title=Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue=2 |pages=345–52 |publisher= |___location = United States| issn = 0006-291X| pmid = 12745081 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)00767-8 }}</ref> and [[Janus kinase 2]].<ref name=pmid9133424>{{cite journal |last=Takeshita |first=T |authorlink= |author2=Arita T |author3=Higuchi M |author4=Asao H |author5=Endo K |author6=Kuroda H |author7=Tanaka N |author8=Murata K |author9=Ishii N |author10=Sugamura K |date=April 1997 |title=STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction |journal=Immunity |volume=6 |issue=4 |pages=449–57 |publisher= |___location = UNITED STATES| issn = 1074-7613| pmid = 9133424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1074-7613(00)80288-5 }}</ref>

==References==

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*{{cite journal |vauthors=Tanaka N, Kaneko K, Asao H, etal |title=Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19129–35 |year= 1999 |pmid= 10383417 |doi=10.1074/jbc.274.27.19129 }}

*{{cite journal |vauthors=Endo K, Takeshita T, Kasai H, etal |title=STAM2, a new member of the STAM family, binding to the Janus kinases |journal=FEBS Lett. |volume=477 |issue= 1–2 |pages= 55–61 |year= 2000 |pmid= 10899310 |doi=10.1016/S0014-5793(00)01760-9 }}

*{{cite journal | authorvauthors=Kato M, Miyazawa K, Kitamura N |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 ___domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37481–7 |year= 2001 |pmid= 10982817 |doi= 10.1074/jbc.M007251200 }}

*{{cite journal |vauthors=Pandey A, Fernandez MM, Steen H, etal |title=Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38633–9 |year= 2001 |pmid= 10993906 |doi= 10.1074/jbc.M007849200

}}

*{{cite journal |vauthors=Steen H, Kuster B, Fernandez M, etal |title=Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1031–9 |year= 2002 |pmid= 11687594 |doi=10.1074/jbc.M109992200 }}

*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}

*{{cite journal | authorvauthors=Bache KG, Raiborg C, Mehlum A, Stenmark H |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12513–21 |year= 2003 |pmid= 12551915 |doi=10.1074/jbc.M210843200 }}

*{{cite journal | authorvauthors=Blackstone C, Roberts RG, Seeburg DP, Sheng M |title=Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1 |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 2 |pages= 345–52 |year= 2003 |pmid= 12745081 |doi=10.1016/S0006-291X(03)00767-8 }}

*{{cite journal |vauthors=Mizuno E, Kawahata K, Kato M, etal |title=STAM proteins bind ubiquitinated proteins on the early endosome via the VHS ___domain and ubiquitin-interacting motif |journal=Mol. Biol. Cell |volume=14 |issue= 9 |pages= 3675–89 |year= 2004 |pmid= 12972556 |doi= 10.1091/mbc.E02-12-0823| pmc=196559 }}

*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}

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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

*{{cite journal |vauthors=Kobayashi H, Tanaka N, Asao H, etal |title=Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2 |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10468–77 |year= 2005 |pmid= 15640163 |doi=10.1074/jbc.M409969200 }}

*{{cite journal | authorvauthors=Row PE, Clague MJ, Urbé S |title=Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties |journal=Biochem. J. |volume=389 |issue= Pt 3 |pages= 629–36 |year= 2005 |pmid= 15828871 |doi= 10.1042/BJ20050067 | pmc=1180712 }}

*{{cite journal |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}

*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}