Restriction fragment length polymorphism: Difference between revisions

Revision as of 07:52, 16 June 2016

Revision as of 18:55, 31 July 2016

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Analysis of RFLP variation in genomes was a vital tool in genome mapping and genetic disease analysis. If researchers were trying to initially determine the chromosomal ___location of a particular disease gene, they would analyze the DNA of members of a family afflicted by the disease, and look for RFLP alleles that show a similar pattern of inheritance as that of the disease (see [[Genetic linkage]]). Once a disease gene was localized, RFLP analysis of other families could reveal who was at risk for the disease, or who was likely to be a [[Genetic carrier|carrier]] of the mutant genes.

RFLP analysis was also the basis for early methods of [[Geneticgenetic fingerprinting]], useful in the identification of samples retrieved from [[forensic|crime]] scenes, in the determination of [[DNA paternity testing|paternity]], and in the characterization of [[genetic diversity]] or breeding patterns in animal populations.

== Alternatives ==