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The CPCRA was one of four networks that NIH was using to conduct clinical trials that were looking to understand possible therapies for people with HIV infection.<ref>{{cite press release |url=https://aidsinfo.nih.gov/news/123/niaid-research-on-aids |title=NIAID Research on AIDS |publisher=aidsinfo.nih.gov |date= 1 January 1995 |accessdate=22 April 2016}}</ref> Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."<ref>[http://cpcra.s-3.com/]</ref>
The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and [[unintended consequence]]s of various treatment strategies using available agents to assess long-term immunologic, virologic and clinical outcomes. CPCRA trials are designed with nested substudies aimed at understanding the pathogenesis of HIV infection and the public health implications of its treatment.<ref>{{cite web|url=http://www.niaid.nih.gov/DAIDs/pdatguide/cpcra.htm |title=Archived copy |accessdate=April 17, 2007 |deadurl=yes |archiveurl=
By 2001, CPCRA had 4,244 people participating in their studies, with trials underway in 17 cities.<ref>{{cite press release |url=https://aidsinfo.nih.gov/news/41/hiv-infection-in-minority-populations |title=HIV Infections in Minority Populations |publisher=aidsinfo.nih.gov |date =1 June 2002 |accessdate=22 April 2016}}</ref>
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