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Scientific studies have examined the relationship between coffee consumption and an array of medical conditions. Findings are contradictory as to whether coffee has any specific health benefits, and results are similarly conflicting regarding negative effects of coffee consumption {{harv|Kummer|2003|pp=151–170}}.
Coffee appears to reduce the risk of [[Alzheimer's disease]], [[Parkinson's disease]], [[heart disease]], [[diabetes mellitus type 2]], [[cirrhosis]] of the [[liver]] {{harv|Klatsky|Morton|Udaltsova|Friedman|2006}}, and [[gout]]. Some health effects are due to the [[caffeine]] content of coffee, as the benefits are only observed in those who drink caffeinated coffee, while others appear to be due to other components {{harv|Pereira|Parker|Folsom|2006}}. For example, the [[antioxidant]]s in coffee prevent [[Radical (chemistry)|free radicals]] from causing cell damage {{harv|Bakalar|2006}}.
Although caffeine has not been linked to any life-threatening disease, doctors and nurses routinely advise some patients to watch their caffeine intake or to eliminate it altogether {{harv|Kummer|2003|p=152}}. Research suggests that drinking caffeinated coffee can cause a temporary increase in the stiffening of arterial walls {{harv|Mahmud|Feely|2001}}. Excess coffee consumption may lead to a [[magnesium deficiency (medicine)|magnesium deficiency]] or [[hypomagnesaemia]] {{harv|Johnson|2001}}, and may be a risk factor for [[coronary heart disease]]. Some studies suggest that it may have a mixed effect on [[short-term memory]], by improving it when the information to be recalled is related to the current [[train of thought]], but making it more difficult to recall unrelated information {{harv|Lesk|2004}}. About 10% of people with a moderate daily intake (235 mg per day) reported increased depression and anxiety when caffeine was withdrawn {{harv|Smith|2002}}, and about 15% of the general population report having stopped caffeine use completely, citing concern about health and unpleasant side effects {{harv|Johns Hopkins|2003}}. Nevertheless, the mainstream view of medical experts is that drinking three 8-ounce (236 ml) cups of coffee per day (considered average or moderate consumption) does not have significant health risks for adults {{harv|Haines|2007}}.
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|last = Klatsky
|first = Arthur L.
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|year = 2006
|title = Coffee, Cirrhosis, and Transaminase Enzymes
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