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Added sections on History, rules guiding KNF model, and comparison to MWC model. Added 4 sources to reference added information. Mainly added the structural differences between MWC and KNF, and negative cooperativity. |
clarified definition, changing from "each" subunit to "neighboring" subunit. Removed ambiguous citation from references. |
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{{Unreferenced|date=January 2009}}
The '''sequential model''' (also known as the '''[[Induced fit#Induced fit model|KNF model]] ''') is a theory that describes co-operativity of [[protein subunit]]s<ref>Koshland, D.E., Némethy, G. and Filmer, D. (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits.
Biochemistry 5, 365–385. [http://pubs.acs.org/doi/abs/10.1021/bi00865a047 DOI: 10.1021/bi00865a047]</ref> It postulates that a protein's conformation changes with each binding of a ligand, thus sequentially changing its affinity for the ligand at
==Overview==
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==References==
{{Reflist}}
[[Category:Protein structure]]
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