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The '''sequential model''' (also known as the '''[[Induced fit#Induced fit model|KNF model]] ''') is a theory that describes co-operativity of [[protein subunit]]s<ref>Koshland, D.E., Némethy, G. and Filmer, D. (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits.
Biochemistry 5, 365–385. [http://pubs.acs.org/doi/abs/10.1021/bi00865a047 DOI: 10.1021/bi00865a047]</ref> It postulates that a protein's conformation changes with each binding of a ligand, thus sequentially changing its affinity for the ligand at neighboring binding sites.
[[File:KNF_model.gif|thumb|Visual representation of the KNF model in a tetrameric protein.]]
==Overview==
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