Azide-alkyne Huisgen cycloaddition: Difference between revisions

Revision as of 13:44, 5 July 2016

Revision as of 00:17, 5 May 2017

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| title = The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification

| author = R.A. Evans

| issue = 6}}</ref> Most variations in coupling polymers with other polymers or small molecules have been explored. Current shortcomings are that the terminal alkyne appears to participate in [[free -radical polymerization]]s. This requires protection of the terminal alkyne with a trimethyl silyl [[protecting group]] and subsequent deprotection after the radical reaction are completed. Similarly the use of organic solvents, copper (I) and inert atmospheres to do the cycloaddition with many polymers makes the "click" label inappropriate for such reactions. An aqueous protocol for performing the cycloaddition with free -radical polymers is highly desirable.

The CuAAC click reaction also effectively couples [[polystyrene]] and [[bovine serum albumin]] (BSA).<ref>{{cite journal