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'''Tunable Resistive Pulse Sensing''' ('''TRPS''') is a technique that allows high-throughput single particle measurements as colloids and/or biomolecular analytes driven through a size-tunable [[nanopore]], one at a time.<ref>Dynamically resizable nanometre-scale apertures for molecular sensing"; Stephen J. Sowerby, Murray F. Broom, George B. Petersen; Sensors and Actuators B: Chemical Volume 123, Issue 1 (2007), pages 325-330</ref><ref>Vogel et al. (2011) "Quantitative Sizing of Nano/Microparticles with a Tunable Elastomeric Pore Sensor" Journal of Analytical Chemistry 83 (9), pp 3499–3506</ref>
The technique adapts the principle of resistive pulse-sensing, which monitors current flow through an aperture, combined with the use of tunable nanopore technology, allowing the passage of ionic current and particles to be regulated by adjusting the pore size.<ref>Roberts et al. (2010) "Tunable Nano/Micropores for Particle Detection and Discrimination: Scanning Ion Occlusion Spectroscopy" Small - Volume 6, Issue 23, pp 2653–2658</ref><ref>Willmott et al. (2010) "Use of tunable nanopore blockade rates to investigate colloidal dispersions" J. Phys.: Condens. Matter 22, 45411</ref> [[Izon Science]] is currently the only manufacturer of nanotechnology instruments that uses TRPS to measure and characterise particles.
[[File:Scanning Ion Occlusion Sensing.png|thumb|Tunable Resistive Pulse Sensing (TRPS). Particles crossing a pore are detected as a transient change in the ionic current flow, which is denoted as a blockade event with its amplitude denoted as the blockade magnitude.]]
== Technique ==
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[[Category:Nanotechnology]]
[[Category:Nanoparticles]]
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