SNP array: Difference between revisions

Revision as of 23:45, 25 May 2006

Revision as of 12:06, 4 October 2006

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In addition, SNP-array can be used for studying the loss of heterozygosity. [[Loss of heterozygosity]] (LOH) is a form of allelic imbalance that can be resulted from the complete loss of an allele or from an increase in copy number of one allele relative to the other. Using high density SNP array to detect LOH allows identification of pattern of allelic imbalance with potential prognostic and diagnostic utilities. This usage of SNP array has a huge potential in the cancer diagnostics as LOH is a prominent characteristics of most human cancer.

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Mei, R., Galipeau, P.C., Prass, C., Berno, A., Ghandour, G., Patil, N., Wolff, R.K., Chee, M.S., Reid, B.J., and Lockhart, D.J., 2000. ''Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays'', Genome Res. 10:1126-1137.

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