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To battle the memory complexity of storing all training instances, as well as the risk of [[overfitting]] to noise in the training set, ''instance reduction'' algorithms have been proposed.<ref>{{cite journal |title=Reduction techniques for instance-based learning algorithms |author1=D. Randall Wilson |author2=Tony R. Martinez |journal=[[Machine Learning (journal)|Machine Learning]] |publisher=Kluwer |year=2000}}</ref>
Gagliardi<ref name=Gagliardi2011>{{cite journal|last=Gagliardi|first=F|title=Instance-based classifiers applied to medical databases: Diagnosis and knowledge extraction|journal=Artificial Intelligence in Medicine|year=2011|volume=52|issue=3|pages=123–139|doi=10.1016/j.artmed.2011.04.002|url=
One of these classifiers (called ''Prototype exemplar learning classifier'' ([[PEL-C]]) is able to extract a mixture of abstracted prototypical cases (that are [[syndrome]]s) and selected atypical clinical cases.
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