X-linked dominant inheritance: Difference between revisions

Revision as of 08:43, 8 August 2017

Revision as of 18:36, 6 September 2017

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Some scholars have suggested discontinuing the terms dominant and recessive when referring to X-linked inheritance due to the multiple mechanisms that can result in the expression of X-linked traits in females, which include cell autonomous expression, skewed X-inactivation, clonal expansion, and somatic mosaicism.<ref>{{cite journal |doi=10.1002/ajmg.a.30123|pmid=15316978|title=Inheritance of most X-linked traits is not dominant or recessive, just X-linked|journal=American Journal of Medical Genetics|volume=129A|issue=2|pages=136|year=2004|last1=Dobyns|first1=William B.|last2=Filauro|first2=Allison|last3=Tomson|first3=Brett N.|last4=Chan|first4=April S.|last5=Ho|first5=Allen W.|last6=Ting|first6=Nicholas T.|last7=Oosterwijk|first7=Jan C.|last8=Ober|first8=Carole}}</ref>

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==Genetics==

As the X chromosome is one of the [[sex chromosome]]s (the other being the [[Y chromosome]]), X-linked

inheritance is determined by the [[sex]] of the parent carrying a specific gene and can often seem complex. This is due to the fact that, typically, [[female]]s have two copies of the X-chromosome, while [[male]]s have only one copy. The difference between [[Dominance (genetics)#Dominant trait|dominant]] and [[Dominance (genetics)#Recessive|recessive]] inheritance patterns also plays a role in determining the chances of a child inheriting an X-linked disorder from their parentage.

Males can only get an X chromosome from their mother whilst females get an X chromosome from both parents. As a result, females tend to show higher prevalence of X-linked dominant disorders because they have more of a chance to inherit a faulty X chromosome.

===Inheritance===

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| align=center valign=center |[[Image:Xlink dominant mother.jpg|thumb|175px]] || align=center valign=center |[[Image:X-link dominant father.jpg|thumb|175px]]