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===Disease===
According to the Journal of Neurology, Neurosurgery, and Psychiatry, [[Alzheimer’s]] generally causes a reduction in tissue as well as neurodegeneration throughout the brain. Out of all areas in the brain, the hippocampus is among the first to be damaged by Alzheimer’s. One study located in the Journal of Neurology, Neurosurgery, and Psychiatry tested to see the volume changes of the hippocampus in Alzheimer’s disease patients. Results showed that there was 27% less volume in the hippocampus compared with the hippocampus found in normal cognition. Lastly, the difference between the hippocampus of an Alzheimer’s patient and that of a normal patient was shown through the notable loss seen in cortical grey matter in Alzheimer’s.<ref name=i>{{cite journal | last1 = Du | first1 = A. | last2 = Schuff | first2 = N. | last3 = Amend | first3 = D. | last4 = Laakso | first4 = M. | last5 = Hsu | first5 = Y. | last6 = Jagust | first6 = W. | last7 = Yaffe | first7 = K. | last8 = Kramer | first8 = J. | last9 = Reed | first9 = B. | last10 = Norman | first10 = D. | last11 = Chui | first11 = H. | last12 = Weiner | first12 = M. | year = 2001 | title = Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and alzheimer's disease | url = | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 71 | issue = | pages = 441–447 | doi=10.1136/jnnp.71.4.441}}</ref>
==Experiment==
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