Complement component 5: Difference between revisions

Revision as of 16:02, 30 August 2017

Revision as of 23:19, 14 November 2017

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== Function ==

Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an [[anaphylatoxin]] that possesses potent [[spasm|spasmogenic]]ogenic and [[chemotaxis|chemotactic]] activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the [[complement component 6|C6 complement component]], and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.<ref name="entrez"/>

== Clinical significance ==

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*{{cite journal | vauthors=Süsal C, Kirschfink M, Kröpelin M |title=Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120 |journal=Blood |volume=87 |issue= 6 |pages= 2329–36 |year= 1996 |pmid= 8630395 |doi= |display-authors=etal}}

*{{cite journal | vauthors=Ames RS, Li Y, Sarau HM |title=Molecular cloning and characterization of the human anaphylatoxin C3a receptor |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20231–4 |year= 1996 |pmid= 8702752 |doi=10.1074/jbc.271.34.20231 |display-authors=etal}}

*{{cite journal | vauthors=Fredslund F, Laursen NS, Roversi P | title=Structure of and influence of a tick complement inhibitor on human complement component 5 | journal=Nat Immunol. |volume= 9 |issue= 7 |pages= 753–60 |year= 2008 |pmid= 18536718 | doi=10.1038/ni.1625 |display-authors=etal}}

{{refend}}

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{{NLM content}}

{{gene-9-stub}}

{{PDB Gallery|geneid=727}}

{{Complement system}}

[[Category:Complement system]]

{{gene-9-stub}}