Reliability theory of aging and longevity: Difference between revisions

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The '''reliability theory of aging''' is an attempt to apply the principles of [[reliability theory]] to create a [[mathematical model]] of [[aging]]. The theory was published in Russian by [[Leonid A. Gavrilov]] and Natalia S. Gavrilova as ''Biologiia prodolzhitelʹnosti zhizni'' in 1986, and in English translation as ''The Biology of Life Span: A Quantitative Approach'' in 1991.{{r|gav|rayl}}
 
One of the models suggested in the book is based on an analogy with the reliability theory. The underlying [[hypothesis]] is based on the (previously suggested) premise that humans are born in a highly defective state. This is then made worse by environmental and mutational damage; exceptionally high [[Redundancy (engineering)|redundancy]] due to the extremely high number of low-reliable components (e.., [[cell (biology)|cell]]s) allows the organism to survive for a while.{{r|ieee}}<ref name=gg2001/>
 
The theory attempts to explain two aging phenomena for higher organisms: the [[Gompertz law]] of exponential increase in mortality rates with age and the "late-life mortality plateau" (mortality deceleration compared to the Gompertz law at higher ages).<ref name=gg2001>Gavrilov, Gavrilova (2001).</ref>