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Line 10: == Function == Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an [[anaphylatoxin]] that possesses potent [[spasm]]ogenic and [[chemotaxis\|chemotactic]] activity, is derived from the alpha polypeptide via cleavage with a [[C5 -convertase]]. The C5b macromolecular cleavage product can form a complex with the [[complement component 6\|C6 complement component]], and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.<ref name="entrez"/> == Clinical significance ==

Complement component 5: Difference between revisions