Human Protein Reference Database: Difference between revisions

Revision as of 20:55, 31 August 2017

Revision as of 19:05, 14 December 2017

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==Overview==

The HPRD is a result of an international collaborative effort between the [http://www.ibioinformatics.org/ Institute of Bioinformatics] in Bangalore, India and the [http://pandeylab.igm.jhmi.edu/ Pandey lab] at [[Johns Hopkins University]] in Baltimore, USA. HPRD contains manually curated scientific information pertaining to the biology of most human proteins. Information regarding proteins involved in human diseases is annotated and linked to [https://www.ncbi.nlm.nih.gov/sites/entrez?db=omim Online Mendelian Inheritance in Man] (OMIM) database. The [https://www.ncbi.nlm.nih.gov/ NationalTheNational Center for Biotechnology Information] provides link to HPRD through its human protein databases (e.g. [https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene Entrez Gene], [https://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq protein]) pertaining to genes and proteins.

This resource depicts information on human protein functions including [[protein–protein interactions]], [[post-translational modifications]], enzyme-substrate relationships and disease associations. Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. The protein–protein interaction and subcellular localization data from HPRD have been used to develop a human protein interaction network.<ref>{{cite journal | author = Gandhi T.K.B. | year = | title = Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets | url = | journal = Nature Genetics | volume = 38| issue = 3| pages = 285–293 | doi=10.1038/ng1747 | pmid=16501559 | date=March 2006|display-authors=etal}}</ref>