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[[Image:Huisgen.png|center|Huisgen 1,3-dipolar cycloaddition]]
In the reaction above<ref>''Development and Applications of Click Chemistry'' Gregory C. Patton November 8, '''2004''' [http://www.chemistry.uiuc.edu/research/organic/seminar_extracts/2004_2005/08_Patton_Abstract.pdf http://www.scs.uiuc.edu Online]{{dead link|date=January 2018 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> azide '''2''' reacts neatly with alkyne '''1''' to afford the triazole '''3''' as a mixture of 1,4-adduct and 1,5-adduct at 98 °C in 18 hours.
The standard 1,3-cycloaddition between an azide 1,3-dipole and an alkene as dipolarophile has largely been ignored due to lack of reactivity as a result of electron-poor olefins and elimination side reactions. Some success has been found with non-metal-catalyzed cycloadditions, such as the reactions using dipolarophiles that are electron-poor olefins<ref>
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