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The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal |vauthors=Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Res | volume = 57 | issue = 18 | pages = 4063–9 |date=Oct 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>
This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal|last1=Han|first1=BG et al.,|title=Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules|journal=J. Biol. Chem.|volume=287|page=10727-37 |doi= 10.1074/jbc.M111.317594.|pmid=22334682}}</ref>
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