API5: Difference between revisions

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{{Infobox_gene}}

The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | vauthors = Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer ResResearch | volume = 57 | issue = 18 | pages = 4063–9 | date =Oct September 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdateaccess-date = }}</ref>

This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal |last1 vauthors = Han|first1= BG, etKim al.KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal =J. Biol.The Journal of Biological Chemistry Chem.| volume = 287 |page issue =10727-37 14 | pages = 10727–37 | date = March 2012 | pmid = 22334682 | doi = 10.1074/jbc.M111.317594 |pmid=22334682}}</ref>

{{reflist}}.

Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].

== Further reading ==

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==External links==

* {{UCSC gene info|API5}}

==Further reading==

{{refbegin | 2}}

* {{cite journal | vauthors = Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A | title = Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 3-4 | pages = 164–6 | year = 1999 | pmid = 10393420 | doi = 10.1159/000015247 }}

{{PBB_Further_reading

* {{cite journal | vauthors = Kim JW, Cho HS, Kim JH, Hur SY, Kim TE, Lee JM, Kim IK, Namkoong SE | title = AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 80 | issue = 4 | pages = 587–94 | date = April 2000 | pmid = 10780674 | doi = 10.1038/labinvest.3780008 }}

| citations =

* {{cite journal | vauthors =Gianfrancesco FVan den Berghe L, EspositoLaurell TH, CiccodicolaHuez AI, Zanibellato C, Prats H, Bugler B | title =Molecular cloningFIF and[fibroblast finegrowth mappingfactor-2 of API5L1(FGF-2)-interacting-factor], a novelnuclear humanputatively geneantiapoptotic stronglyfactor, relatedinteracts tospecifically anwith antiapoptotic gene.FGF-2 | journal =Cytogenet. CellMolecular Genet.Endocrinology | volume =84 14 | issue = 3-411 | pages = 164–61709–24 |year date = 1999November 2000 | pmid = 1039342011075807 | doi = 10.11591210/000015247me.14.11.1709 |display-authors=etal}}

* {{cite journal | vauthors =Kim JWSutherland HG, ChoMumford HSGK, KimNewton JHK, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA | title =AAC Large-11scale overexpressionidentification inducesof invasionmammalian andproteins protectslocalized cervicalto cancernuclear cellssub-compartments from| apoptosis.journal |journal=Lab. Invest.Human Molecular Genetics | volume =80 10 | issue = 418 | pages = 587–941995–2011 |year date = 2000September 2001 | pmid = 1078067411555636 | doi = 10.10381093/labinvesthmg/10.378000818.1995 |display-authors=etal}}

* {{cite journal | vauthors =Van denLi BergheZ, Hu CY, Mo LBQ, LaurellXu HJD, HuezZhao IY | title =FIF [fibroblastEffect growthof factorbeta-2carotene (FGF-2)-interacting-factor],on agene nuclearexpression putativelyof antiapoptoticbreast factor,cancer interactscells] specifically| withjournal FGF-2.= Ai Zheng |journal=Mol. Endocrinol.Aizheng = Chinese Journal of Cancer | volume =14 22 | issue = 114 | pages = 1709–24380–4 |year date = 2001April 2003 | pmid = 1107580712703993 | doi=10.1210/me.14.11.1709 |display-authors=etal }}

* {{cite journal | vauthors =Sutherland HGAndersen JS, MumfordLam GKYW, NewtonLeung KAK, |title=Large-scaleOng identificationSE, ofLyon mammalianCE, proteinsLamond localizedAI, toMann nuclearM sub-compartments.| title = Nucleolar proteome dynamics | journal =Hum. Mol. Genet.Nature | volume =10 433 | issue = 187021 | pages = 1995–201177–83 |year date = 2001January 2005 | pmid = 1155563615635413 | doi = 10.10931038/hmg/10.18.1995nature03207 |display-authors=etal}}

* {{cite journal | vauthors =Strausberg RLKim JE, FeingoldTannenbaum EASR, GrouseWhite LHFM | title=Generation and= initialGlobal analysisphosphoproteome of more than 15,000 fullHT-length29 human andcolon mouseadenocarcinoma cDNAcells sequences.| |journal =Proc. Natl.Journal Acad.of Sci.Proteome U.S.A.Research | volume =99 4 | issue = 264 | pages = 16899–9031339–46 | year = 20032005 | pmid = 1247793216083285 | doi = 10.10731021/pnas.242603899pr050048h | pmc=139241 |display-authors=etal}}

* {{cite journal | vauthors =Li ZOlsen JV, HuBlagoev CYB, MoGnad BQF, Macek B, Kumar C, Mortensen P, Mann M | title =[Effect ofGlobal, beta-carotenein onvivo, geneand expressionsite-specific ofphosphorylation breastdynamics cancerin cells]signaling networks | journal =Ai ZhengCell | volume =22 127 | issue = 43 | pages = 380–4635–48 |year date = 2003November 2006 | pmid = 1270399317081983 | doi= |display-authors=etal 10.1016/j.cell.2006.09.026 }}

* {{cite journal | vauthors =Gerhard DSMorris EJ, WagnerMichaud LWA, FeingoldJi EAJY, |title=TheMoon statusNS, qualityRocco JW, andDyson expansionNJ of| thetitle NIH= full-lengthFunctional cDNAidentification project:of theApi5 Mammalianas Genea Collectionsuppressor (MGC).of E2F-dependent apoptosis in vivo | journal =Genome Res.PLoS Genetics | volume =14 2 | issue = 10B11 | pages = 2121–7e196 |year date = 2004November 2006 | pmid = 1548933417112319 | pmc = 1636698 | doi = 10.11011371/grjournal.2596504pgen.0020196 |}} pmc=528928{{open |display-authors=etalaccess}}

*{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}

*{{cite journal |vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}

*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}

*{{cite journal |vauthors=Morris EJ, Michaud WA, Ji JY |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 | pmc=1636698 |display-authors=etal}} {{open access}}

}}

*{{cite journal|last1=Han|first1=BG et al.,|title=Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules|journal=J. Biol. Chem.|volume=287|page=10727-37 |doi= 10.1074/jbc.M111.317594|pmid=22334682}}

{{refend}}

== External links ==

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* {{UCSC gene info|API5}}

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