Content deleted Content added
removed no longer needed PBB controls and templates consistent citation formatting; removed further reading citations not specific to this gene |
restored references section |
||
Line 3:
This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = The Journal of Biological Chemistry | volume = 287 | issue = 14 | pages = 10727–37 | date = March 2012 | pmid = 22334682 | doi = 10.1074/jbc.M111.317594 }}</ref>
{{reflist}}.▼
Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].
== References==
== Further reading ==
| |||