Push–pull perfusion: Difference between revisions

Content deleted Content added
url unnecessary if DOI given
m top: task, removed: (London)
Line 1:
'''Push–pull perfusion''' is an [[in vivo]] sampling method most commonly used for measuring neurotransmitters in the brain. Developed by J.H. Gaddum in 1960,<ref>{{cite journal|last=Gaddum|first=J.H.|title=Push-pull cannulae|journal=Journal of Physiology (London)|year=1961|volume=155|issue=1|pages=1P–2P}}</ref>
this technique replaced the [[cortical cup]] technique for observing neurotransmitters. The advent of concentric [[microdialysis]] probes in the 1980s resulted in push-pull sampling falling out of favor, as such probes require less monitoring, and are less invasive than the higher flow rate push-pull probes (>10&nbsp;microliter/min), which could result in lesions if flow is unbalanced.<ref>{{cite journal|last=Myers|first=R.D.|author2=Adell, A. |author3=Lankford, M.F. |title=Simultaneous comparison of cerebral dialysis and push-pull perfusion in the brain of rats: a critical review|journal=Neuroscience & Biobehavioral Reviews|year=1998|volume=22|issue=3|pages=371–387|doi=10.1016/S0149-7634(97)00025-0 }}</ref>