Cardiac neural crest: Difference between revisions

Revision as of 11:06, 30 August 2017

Revision as of 22:09, 19 November 2018

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== CNCCS and ischaemic heart disease ==

There is interest amongst researchers as to whether CNCCs can be used to repair human heart tissue. [[Myocardial infarction|Heart attacks]] in humans are common and their rate of mortality is high. There are emergency treatments that hospitals can administer, such as [[angioplasty]] or [[surgery]], but after that patients will likely be on medication for the long term and are more susceptible to heart attacks in the future. Other complications of heart attacks include [[cardiac arrhythmia]]s and [[heart failure]].<ref name= "Canada (2012)">[http://www.heartandstroke.com/site/c.ikIQLcMWJtE/b.3483991/k.34A8/Statistics.htm "Canadian Heart and Stroke Foundation statistics."] {{Webarchive|url=https://web.archive.org/web/20121203175846/http://www.heartandstroke.com/site/c.ikIQLcMWJtE/b.3483991/k.34A8/Statistics.htm# |date=2012-12-03 }} Canadian Heart and Stroke Foundation Accessed 20 November 2012.</ref>

Although CNCCs are important in embryos, some CNCCs are retained in a dormant state to adulthood where they are called ''[[neural crest]] [[stem cells]]''. In 2005, Tomita transplanted neural crest stem cells from mammal hearts to the neural crest of chick embryos. These CNCCs were shown to migrate into the developing heart of the chick using the same dorsolateral pathway as the CNCCs, and differentiate into neural and glial cells.<ref name="Tomita (2005)">Tomita Y. et al "Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart." J Cell Biol September 2005, 170(7) p1135 - 1146 {{PMC|2171522}} {{PMID|16186259}} {{doi|10.1083/jcb.200504061}} Accessed 20 November 2012.</ref>