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===Significance analysis of microarrays (SAM)===
{{main|Significance analysis of microarrays}}
Significance analysis of microarrays (SAM) is a [[statistics|statistical technique]] for determining whether changes in [[gene expression]] are statistically significant. It was established in 2001 by Virginia Tusher, [[Robert Tibshirani]] and [[Gilbert Chu]], and is distributed in an [[R (programming language)|R-package]] by [[Stanford University]].
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