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Interactions between various aspects (people, activities, and components) is done using additional (non-square) linkage matrices. The Multiple Domain Matrix (MDM) is an extension of the basic DSM structure.<ref>Maurer M (2007) Structural Awareness in complex product design. Dissertation, Technischen Universität München, Germany</ref> A MDM includes several DSMs (ordered as block diagonal matrices) that represent the relations between elements of the same ___domain; and corresponding Domain Mapping Matrices (DMM) <ref>M. Danilovic; T. R. Browning: [https://dx.doi.org/10.1007/s10951-009-0131-y "Managing Complex Product Development Projects with Design Structure Matrices and Domain Mapping Matrices"]. In: ''International Journal of Project Management.'' 25(3), 2007, S. 300-314.</ref> that represent relations between elements of different domains.
The use of DSM has been extended to visualize and optimize the otherwise invisible information flow and interactions associated with office work. This visualization via DSM allows the Lean Body of Knowledge to be applied to office and information intensive flows.<ref>{{cite book|title=Far From the Factory: Lean for the Information Age|year=2010|publisher=Productivity Press|___location=New York|isbn=
The DSM method was applied as a framework for analyzing the propagation of rework in product development processes, and the related problem of convergence (or divergence) using the theory of linear dynamical systems.<ref name="complex"/><ref>Smith R, Eppinger S (1997) “Identifying controlling features of engineering design iteration.” Management Science 43(3):276–293. </ref><ref> Yassine A, Joglekar N, Braha D, Eppinger S, and Whitney D (2003),"Information hiding in product development: the design churn effect." Research in Engineering Design, 14(3): 131-144.</ref>
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